Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice.

FEBS Letters
Linjie ChenJianxin Lyu

Abstract

Regeneration is a unique defense mechanism of liver tissue in response to functional cell loss induced by toxic chemicals or surgical resection. In this study, we found that Islet-cell autoantigen 69 (Ica69) accelerates liver regeneration in mice. Following 70% partial hepatectomy, both Ica69 mRNA and protein are significantly upregulated in mouse hepatocytes at the early stage of liver regeneration. Compared with the wild-type mice, Ica69-deficient mice have more severe liver injury, delayed liver regeneration, and high surgical accidental mortality following hepatectomy. Mechanistically, Ica69 interacts with Pick1 protein to regulate Tgfbr1 protein expression and Tgfβ-induced Smad2 phosphorylation. Our findings suggest that Ica69 in liver tissue is a new potential target for promoting liver regeneration.

References

Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T IchikawaI Kojima
Sep 24, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehrdad NikfarjamChristopher Christophi
Sep 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shoshiro OeSnorri S Thorgeirsson
Apr 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Esther BaenaIgnacio Moreno de Alborán
Jun 3, 2006·Cancer Research·Feng LiLinda A Lee
Aug 17, 2006·Genes & Development·Ewa StepniakErwin F Wagner
Mar 6, 2007·Development, Growth & Differentiation·Shoji HataHiroshi Nishina
Jun 15, 2007·Journal of Cellular Physiology·George K Michalopoulos
Nov 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mian CaoJun Xia
Dec 26, 2007·The Journal of Experimental Medicine·Kimberly J RiehleNelson Fausto
Jan 12, 2008·European Journal of Cell Biology·Laura BuffaMichele Solimena
Jun 2, 2010·The Journal of Experimental Medicine·Karen J HoSeth J Karp
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M NinomiyaY Maehara
Jun 20, 2012·Cell Research·Bing ZhaoYe-Guang Chen
Aug 19, 2016·Science Translational Medicine·Fuqin FanDawang Zhou
Sep 28, 2017·Mediators of Inflammation·Yachao TaoHong Tang
Oct 23, 2018·Scandinavian Journal of Gastroenterology·Stefan GilgBengt Isaksson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.