Islet dysfunction in obese women with impaired glucose tolerance

Metabolism: Clinical and Experimental
H Larsson, Bo Ahrén

Abstract

Insulin sensitivity and islet function were examined in 22 obese women: 11 with normal glucose tolerance (mean +/- SD body mass index [BMI], 32.2 +/- 2.8 kg/m2) and 11 with impaired glucose tolerance (BMI, 30.1 +/- 2.2 kg/m2). Thirteen non-obese women with normal glucose tolerance (BMI, 20.9 +/- 1.3 kg/m2) served as controls. All women were 58 to 59 years of age. Insulin sensitivity was measured with the euglycemic, hyperinsulinemic clamp. Insulin secretion was studied after intravenous arginine (5 g) at fasting, and at blood glucose levels of 14 and greater than 25 mmol/L. Insulin sensitivity was higher in non-obese (99.8 +/- 11.5 nmol/kg/min/pmol insulin/L) than in obese subject (P < or = .002), but did not differ between obese subjects with normal versus impaired glucose tolerance (47.2 +/- 8.8 v 45.5 +/- 5.2 nmol/kg/min/pmol insulin/L, difference not significant [NS]). Obese subjects with normal glucose tolerance had a higher insulin response to both glucose (P < or = .004) and arginine (P < or = .02) than nonobese women, and higher glucose potentiation of insulin secretion, slopeAIR (P = .05). Compared with obese subjects with normal glucose tolerance, the obese subjects with impaired glucose tolerance had a lower insulin ...Continue Reading

Citations

Sep 24, 2004·Transplantation·Ippei MatsumotoBernhard J Hering
Nov 25, 2004·Diabetes·J-L Chiasson, Rémi Rabasa-Lhoret
Oct 12, 1999·The American Journal of Physiology·B Ahrén, P J Havel
Jan 12, 2005·Diabetes, Obesity & Metabolism·B Ahrén, G Pacini
Jun 13, 2017·Diabetes·Jennifer D DeemMichael W Schwartz
Dec 1, 1996·Acta Diabetologica·B Ahrén, H Larsson
Jan 30, 1999·The Journal of International Medical Research·E AdeyemiA Abdulle
Jan 31, 2003·American Journal of Physiology. Endocrinology and Metabolism·Marie GuldstrandUlf Adamson
Nov 14, 1997·The American Journal of Physiology·B Ahrén, G Pacini

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