Islet encapsulated implantable composite hollow fiber membrane based device: A bioartificial pancreas

Materials Science & Engineering. C, Materials for Biological Applications
Rohit S TeotiaJayesh R Bellare

Abstract

Islets from xeno-sources and islet like clusters derived from autologus stem cells have emerged as alternatives to cadaveric pancreas used for treatment of type 1 diabetes. However, the immuno-isolation of these islets from the host immune system suffers from the issue of biocompatibility and hypoxia. To overcome the issues of immunobarrier biocompatibility, we developed a Polysulfone (Psf)/TPGS composite hollow fiber membrane (HFM) using a hollow fiber spinning pilot plant specially developed for this purpose. Important structural variables such as fiber material, dope composition, dimensions, surface characteristics etc., were precisely engineered and tuned for bioartificial pancreas application. The HFMs were characterized for their morphology, molecular diffusion, selectivity and protein absorption. The optimized Polysulfone(Psf)/TPGS composite HFMs, which contained TPGS, exhibited uniformed structure with low insulin adsorption and high permeability of insulin. The HFM was further studied for the encapsulation and in-vitro growth with porcine and differentiated islets isolated from human umbilical cord Wharton's jelly. To prove their efficacy under in-vivo conditions, the Polysulfone(Psf)/TPGS composite HFMs were encapsula...Continue Reading

Citations

Sep 1, 2017·Biomedical Materials·Kevin RobertsJeffrey C Wolchok
Jun 28, 2018·Tissue Engineering. Part B, Reviews·Caden DuffyAlonzo D Cook
Aug 2, 2017·Current Opinion in Organ Transplantation·Maheswaran DhanasekaranAppakalai N Balamurugan
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Aakanksha RuhelaChandra S Sharma

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