Islet Microencapsulation: Strategies and Clinical Status in Diabetes

Current Diabetes Reports
Mustafa OmamiJosé Oberholzer

Abstract

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that results from the destruction of insulin-producing pancreatic β cells in the islets of Langerhans. Islet cell transplantation has become a successful therapy for specific patients with T1DM with hypoglycemic unawareness. The reversal of T1DM by islet transplantation is now performed at many major medical facilities throughout the world. However, many challenges must still be overcome in order to achieve continuous, long-term successful transplant outcomes. Two major obstacles to this therapy are a lack of islet cells for transplantation and the need for life-long immunosuppressive treatment. Microencapsulation is seen as a technology that can overcome both these limitations of islet cell transplantation. This review depicts the present state of microencapsulated islet transplantation. Microencapsulation can play a significant role in overcoming the need for immunosuppression and lack of donor islet cells. This review focuses on microencapsulation and the clinical status of the technology in combating T1DM.

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Citations

May 22, 2019·Advanced Healthcare Materials·Alexander U ErnstMinglin Ma
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alexander Ulrich ErnstMinglin Ma
Jun 20, 2019·Frontiers in Bioengineering and Biotechnology·Shuixan Hu, Paul de Vos
Nov 15, 2020·Materials·Miriam Salles PereiraLuiz Anastacio Alves
Feb 24, 2021·Biomaterials Science·Paola Leon PlataYing Liu
Feb 5, 2019·Advanced Drug Delivery Reviews·Alexander U ErnstMinglin Ma
Dec 29, 2020·Chemical Reviews·Stephanie FuchsMinglin Ma

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