Islet microRNAs in health and type-2 diabetes

Current Opinion in Pharmacology
Anna WendtLena Eliasson

Abstract

Failure of the β-cell to secrete enough insulin is a major contributing factor in the pathogenesis of type-2 diabetes (T2D). MicroRNAs provide an extra layer in the regulation of protein expression, and are thus involved in β-cell compensation during development of the disease. In this review, we discuss how microRNAs can regulate their target protein expression and phenotypic output, present the status of nutritional regulation of microRNA expression, and summarize work on microRNA expression in human islets. In conclusion, current data lend support to microRNAs being essential regulators of insulin secretion. Future work will describe microRNAs in α-cell function, details of the microRNA-mRNA network, and possibilities to use microRNAs as biomarkers and in therapeutic treatment of T2D and complications.

Citations

Jan 30, 2020·Scientific Reports·Takahiro Nemoto, Yoshihiko Kakinuma
Aug 13, 2020·Nature Reviews. Drug Discovery·Thomas C RobertsMatthew J A Wood
Oct 20, 2019·Journal of Molecular Biology·Lena Eliasson, Romano Regazzi
Jan 23, 2021·Diagnostics·Nurruzanna IsmailSiti Aishah Sulaiman
Jan 28, 2020·Seminars in Cell & Developmental Biology·Anna Wendt, Lena Eliasson
Jul 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Bashar SaadAbdalsalam Kmail
Jul 26, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Nirali PandyaAmit Kumar

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