Islet nerves in focus--defining their neurobiological and clinical role.

Diabetologia
B Ahrén

Abstract

Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology.

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Citations

Jun 27, 2013·Diabetologia·Shiue-Cheng TangYa-Yuan Fu
Feb 8, 2014·PloS One·Maggie M HoSusanne M Clee
Sep 10, 2014·Diabetes, Obesity & Metabolism·S-C TangH-J Chien
Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J ChienS-C Tang
Feb 26, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C LubaczeuskiM L Bonfleur
Jun 25, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pei-Yu LinShiue-Cheng Tang
Jan 16, 2014·American Journal of Physiology. Endocrinology and Metabolism·Jyuhn-Huarng JuangShiue-Cheng Tang
Sep 8, 2020·Diabetologia·Mark A AtkinsonKlaus H Kaestner
Nov 9, 2019·Scientific Reports·Yuzuru ItoYasuo Terauchi
Sep 30, 2018·Current Diabetes Reports·Shiue-Cheng TangMartha Campbell-Thompson
Mar 24, 2021·Scientific Reports·Martha Campbell-ThompsonMark A Atkinson

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