Islet organ, blood glucose and glucose tolerance of lean and obese Mongolian gerbils. A quantitative study

Cell and Tissue Research
J M Lucocq, J A Findlay

Abstract

Gerbils were divided, on the basis of body weight, into obese (greater than 80 gms) and lean (less than 80 gms) groups. Fasting blood glucose estimations on all 31 gerbils, and glucose tolerance tests on 9 lean and 6 obese animals, were carried out. All lean and some obese gerbils were normoglycaemic and other obese were hyperglycaemic. All obese gerbils exhibited glucose intolerance. General morphological studies were undertaken as follows: (i) assessment of mesenteric fat deposits, (ii) measurement of anterior abdominal wall thickness, (iii) ratio of animal length to width at specified loci (index of shape). The degree of obesity was less than previously reported in this species though blood glucose abnormality was comparable. The index of animal shape showed a strong correlation with body weight. The following kinds of histological observation were made on pancreases from 4 lean and 4 obese gerbils: (i) % islet representation, (ii) islet size distribution, (iii) beta-cell granularity, (iv) islet vascularity, (v) islet/duct association, (vi) proportions of alpha- and D-cells, (vii) glycogen deposition in islet and duct cells. The pancreases of obese gerbils contained a higher proportion of islet tissue than those of lean due ...Continue Reading

References

Oct 1, 1974·Journal of Wildlife Diseases·L KarstadS Drevemo
Jul 1, 1972·Diabetologia·P H WiseE Forrest
Sep 1, 1969·Diabetes·G Brosky, J Logothetopoulos
Apr 1, 1967·Diabetologia·M Nakamura, K Yamada
Dec 1, 1960·Acta Endocrinologica·C HELLERSTROEM, B HELLMAN
Feb 14, 1964·Science·K SCHMIDT-NIELSEND B HACKEL
Jan 22, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·M NAKAMURA
Dec 1, 1950·The Journal of Heredity·A M INGALLSG D SNELL

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Citations

Sep 24, 2004·Transplantation·Ippei MatsumotoBernhard J Hering
Oct 13, 2009·Diabetes, Obesity & Metabolism·C W LiewR N Kulkarni
Oct 3, 2008·Pediatric Diabetes·Anke AssmannRohit N Kulkarni
Oct 3, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Bernard G SlavinJanis S Fisler
Oct 23, 1997·Biochemical and Biophysical Research Communications·M S IslamV Emilsson
Nov 28, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M S IslamV Emilsson

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