PMID: 6114005Jul 1, 1981Paper

Islet secretion in a new experimental model for non-insulin-dependent diabetes

Diabetes
G C WeirS Bonner-Weir

Abstract

An animal model of diabetes mellitus has been developed in which neonatal rats are injected with streptozotocin at 2 days of age. After transient hyperglycemia followed by near normal glycemia, these animals develop nonketotic diabetes at about 6 wk of age that does not require insulin treatment. Secretion form the endocrine pancreas of 6-15-wk-old rats was evaluated with the isolated, perfused pancreas technique. Insulin secretion responded very poorly to high perfusate glucose concentrations, but in the presence of theophylline this meager response was enhanced. In contrast, arginine elicited an insulin response comparable to that of the control rats. Isoproterenol stimulated insulin secretion more in the diabetic model than in the controls, and tolbutamide failed to evoke insulin secretion. Glucagon secretion in response to arginine and isoproterenol was similar in both groups, but was suppressed less efficiently be glucose in the model than in controls. Evidence for enhanced basal secretion of somatostatin was also found. Thus, these hyperglycemic rats have a selective defect in glucose-stimulated insulin secretion with preservation of responses to other agents. In addition, abnormalities in the secretion of glucagon and so...Continue Reading

Citations

Sep 18, 1991·Molecular and Cellular Biochemistry·S W Schaffer
Sep 18, 1991·Molecular and Cellular Biochemistry·R S KaplanS W Schaffer
Oct 1, 1983·Physiology & Behavior·T J Bartness, N E Rowland
Jun 1, 1995·Physiology & Behavior·H E WencelR S Surwit
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·V M AltanA Ozüari
Oct 1, 1990·Immunology Today·R J Noelle, E C Snow
Sep 30, 1986·Biochemical and Biophysical Research Communications·J LevyJ R Gavin
Jun 4, 1999·European Journal of Pharmacology·N FurukawaK Wakitani
Nov 6, 1982·Lancet·T HelgasonJ M Stowers
Feb 26, 2003·Cancer Detection and Prevention·Claudia CoccaRosa Bergoc
Nov 13, 2004·The Journal of Nutritional Biochemistry·H SoneY Furukawa
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C CoccaR M Bergoc
Nov 21, 1998·European Journal of Clinical Investigation·A SchäfflerK Palitzsch
Feb 6, 2003·Autonomic & Autacoid Pharmacology·M S VattaB E Fernandez
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathrin MaedlerMarc Y Donath
Feb 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Desiree M SchumannMarc Y Donath
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B ThorensS Bonner-Weir
Jul 1, 1992·British Journal of Pharmacology·D Hillaire-BuysM M Loubatières-Mariani
Dec 23, 2011·American Journal of Physiology. Cell Physiology·Jinxu LiuYu-Long Li
Jun 1, 1983·The Journal of Clinical Investigation·S Bonner-WeirG C Weir

❮ Previous
Next ❯