PMID: 2504637Sep 1, 1989Paper

Islet transplantation in spontaneously diabetic BB/Wor rats

Diabetes
O D HegreJ R Serie

Abstract

We investigated the effectiveness of islet transplantation as therapy in an animal model of spontaneous type I (insulin-dependent) diabetes mellitus. Grafting MHC-matched and -mismatched islets with the spontaneously diabetic BB rat as a model has been previously reported to result in recurrence of the disease in the grafted tissue. When transplanted with nonimmunogenic islets isolated by nonenzymatic culture, we found that MHC-matched grafts proved to be susceptible to disease recurrence when allowed to remain in situ until ketosis developed in the host. Conversely, the MHC-mismatched grafts did not succumb to the disease process despite the destruction of the beta-cell population of the endogenous pancreas. Four manifestly hyperglycemic BB/Wor rats received sufficient islet mass by allotransplantation to reverse this state. All four animals had ameliorated conditions, and three of the four were restored to a normoglycemic state. Recurrence of diabetes in the BB rat was not observed.

Citations

Apr 1, 1992·Diabetes/metabolism Reviews·L CrisáA A Rossini
Jun 1, 1991·Diabetologia·D PipeleersG Klöppel
Sep 1, 1978·In Vitro·J A McAteer, O D Hegre
Oct 1, 1991·Annals of Surgery·A M PosseltC F Barker
Feb 1, 1992·The Journal of Clinical Investigation·S B Koevary, M Blomberg
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K B YderstraedeC F Gotfredsen
Apr 1, 1991·Journal of Microencapsulation·H A ClaytonR F James

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