PMID: 22587516May 17, 2012Paper

Islets from rats and pigs transgenic for photogenic proteins

Current Diabetes Reviews
Takumi TerataniEiji Kobayashi

Abstract

Translational research is necessary for the development of efficient experimental animal models that can be used to develop innovative medical treatments, such as improvements in organ or tissue transplantation. We have developed animal models that produce photogenic proteins in their islet cells: rats models expressing the gene for luciferase or green fluorescent protein (GFP), and pig models expressing the gene for GFP or Kusabira-Orange. We also developed methods for preserving isolated islets in culture and showed that the fluorescence of the islets remains at usable levels for at least seven days. These models will enable transplanted islets to be visualized without the need for chemical reactions, and will be useful for research on the biology of islets as well as for the development of new transplantation methods.

Citations

Nov 23, 2012·Diabetes·Jeff W M Bulte
Oct 16, 2013·Current Opinion in Organ Transplantation·Santosh NagarajuDavid K C Cooper
Oct 11, 2017·Experimental Animals·Eiji KobayashiSatoshi Kunita

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