Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site

European Journal of Pharmacology
Matthias PaulC Spencer Yost

Abstract

Administration of certain combinations of non-depolarising muscle relaxants produces greater than expected neuromuscular blockade. Synergistic effects may be explained by drug interactions with the postsynaptic muscle nicotinic acetylcholine receptor. To investigate this hypothesis, the adult mouse muscle nicotinic acetylcholine receptor (alpha(2)beta delta epsilon) was heterologously expressed in Xenopus laevis oocytes and activated by the application of acetylcholine (10 microM). The effects of five individually applied muscle relaxants and six combinations of structurally similar and dissimilar compounds were studied. Drug combinations containing equipotent concentrations of two agents were tested and dose-response curves were determined. All compounds tested alone and in combination produced rapid and readily reversible, concentration-dependent inhibition. Isobolographic and fractional analyses indicated additive interactions for all six tested combinations. These findings suggest that synergistic neuromuscular blocking effects, observed for the administration of certain combinations of muscle relaxants, do not result from purely postsynaptic binding events at the muscle nicotinic acetylcholine receptor, but rather from dif...Continue Reading

References

Nov 1, 1976·Clinical and Experimental Pharmacology & Physiology·W C Bowman, S N Webb
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S E Pedersen, J B Cohen
Feb 1, 1986·Anaesthesia·S K PanditR K Mirakhur
Mar 1, 1971·Anesthesia and Analgesia·K C Wong, J R Jones
Jan 1, 1972·Canadian Anaesthetists' Society Journal·M M GhoneimJ P Long
Mar 1, 1981·British Journal of Anaesthesia·F T Schuh
Aug 1, 1995·Acta Anaesthesiologica Scandinavica·P RautomaO A Meretoja
Oct 1, 1993·British Journal of Anaesthesia·M Naguib, M Abdulatif
Oct 1, 1994·British Journal of Anaesthesia·M NaguibM A Magboul
Sep 1, 1993·British Journal of Anaesthesia·O A MeretojaL Jalkanen
Feb 20, 1993·Journal of Molecular Biology·N Unwin
Oct 1, 1995·Acta Anaesthesiologica Scandinavica·P RautomaI Kalli
Feb 1, 1997·Cellular and Molecular Neurobiology·C S Yost, B D Winegar
Oct 27, 1998·European Journal of Pharmacology·C M GarlandR J Walker
Oct 1, 1951·Annals of the New York Academy of Sciences·W F RIKER, W C WESCOE

❮ Previous
Next ❯

Citations

Mar 7, 2003·European Journal of Pharmacology·M Alexandrina TimóteoPaulo Correia-de-Sá
Jun 10, 2010·Korean journal of anesthesiology·Soo-Il Lee
Jun 10, 2015·Antimicrobial Agents and Chemotherapy·Marcia F da SilvaAlejandro M Katzin
Dec 4, 2020·World Journal of Clinical Cases·Eun-A JangSeongheon Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.