Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
H F Miranda, G Pinardi

Abstract

The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal anti-inflammatory drugs, when coadministered intraperitoneally and intrathecally (i.t.). The simultaneous intraperitoneal administration of fixed ratios of ED(50) fractions of all nonsteroidal anti-inflammatory drugs (naproxen, piroxicam, paracetamol, dipyrone or metamizol and nimesulide) combined with clonidine resulted in synergistic interactions. The same combinations administered intrathecally were additive. The synergistic interactions between systemic nonsteroidal anti-inflammatory drugs and clonidine may involve supraspinal mechanisms.

Citations

Feb 12, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·M SoukupováM Krsiak
Nov 6, 2010·Archives of Pharmacal Research·Mario I OrtizRaquel Cariño-Cortés
Oct 23, 2012·Indian Journal of Anaesthesia·Aloka SamantarayAbha Chandra
Oct 8, 2014·Anesthesiology and Pain Medicine·Fatemeh ZeraatiMohammad Hadi Farjoo
Apr 22, 2015·Pharmaceutical Biology·Bahareh NaghizadehBehnam Ghorbanzadeh
Mar 19, 2013·European Journal of Pharmacology·Antti Pertovaara
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Oct 27, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roberto T SudoIvan R Pitta

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