Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury

The Journal of Nutritional Biochemistry
Andrew A PierceJacquelyn J Maher

Abstract

Diets containing excess carbohydrate and fat promote hepatic steatosis and steatohepatitis in mice. Little is known, however, about the impact of specific carbohydrate/fat combinations on liver outcome. This study was designed to determine whether high-energy diets with identical caloric density but different carbohydrate and fat composition have unique effects on the liver. Four experimental diets were formulated with 60%kcal carbohydrate and 20%kcal fat, each in nearly pure form from a single source: starch-oleate, starch-palmitate, sucrose-oleate and sucrose-palmitate. The diets were fed to mice for 3 or 12 weeks for analysis of lipid metabolism and liver injury. All mice developed hepatic steatosis over 12 weeks, but mice fed the sucrose-palmitate diet accumulated more hepatic lipid than those in the other three experimental groups. The exaggerated lipid accumulation in sucrose-palmitate-fed mice was attributable to a disproportionate rise in hepatic de novo lipogenesis. These mice accrued more hepatic palmitate and exhibited more evidence of liver injury than any of the other experimental groups. Interestingly, lipogenic gene expression in mice fed the custom diets did not correlate with actual de novo lipogenesis. In addi...Continue Reading

References

Jul 1, 1977·The Journal of Clinical Investigation·J D McGarryD W Foster
May 1, 1991·The Journal of Clinical Investigation·M K HellersteinC H Shackleton
Aug 1, 1985·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·J E Vance, D E Vance
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Sara BassilianW-N Paul Lee
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoGianfranco Pagano
Jun 12, 2003·American Journal of Physiology. Endocrinology and Metabolism·Daniel Z BrunengraberStephen F Previs
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
May 3, 2005·The Journal of Clinical Investigation·Kerry L DonnellyElizabeth J Parks
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Nov 28, 2006·The Journal of Biological Chemistry·Harini SampathJames M Ntambi
May 2, 2007·Gut·Harmeet MalhiGregory J Gores
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naoto MatsuzawaShuichi Kaneko
Apr 9, 2008·Journal of Hepatology·Xiaosen OuyangManal F Abdelmalek
Sep 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Laura H TetriBrent A Neuschwander-Tetri
Mar 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 12, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Michael K PickensJacquelyn J Maher
Jul 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit KohliRandy J Seeley
Aug 13, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CharltonGregory Gores
Apr 18, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christopher SavardGeorge N Ioannou
Jul 17, 2012·Clinics and Research in Hepatology and Gastroenterology·Luc Tappy, Kim-Anne Lê
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joy X JiangNatalie J Török
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takuji IshimotoRichard J Johnson
Jul 26, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D Samocha-BonetE Ravussin
Aug 8, 2014·The American Journal of Clinical Nutrition·Noora KanervaJohan G Eriksson
Jan 13, 2015·The Journal of Nutritional Biochemistry·Jamie E MellsFrank A Anania
Mar 20, 2015·The Journal of Nutrition·Emma L AndersonDebbie A Lawlor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.