PMID: 2487154Nov 1, 1989Paper

Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system

Genes, Chromosomes & Cancer
J A BiegelB S Emanuel

Abstract

We have prepared karyotypes from 22 primitive neuroectodermal tumors (PNETs) from pediatric patients ranging in age from 10 months to 16 years. Twenty-one cases were newly diagnosed, primary, posterior fossa tumors. One case was a recurrent tumor in a patient previously treated with radiation. Cytogenetic results were obtained from direct preparations and/or short-term (1-10 day) culture. Three tumors had apparently normal karyotypes. Nineteen tumors demonstrated numerical and/or structural abnormalities. The most frequent structural chromosomal changes were deletions and nonreciprocal translocations. Four tumors contained double minutes. Several chromosomes appear to be nonrandomly involved in PNETs. These include chromosomes 5, 6, 11, 16, 17, and a sex chromosome. The most consistent change, however, was an i(17q), present in one-third (8/22) of the cases. Strikingly, in three of these eight tumors, the i(17q) was the only structural abnormality observed. An i(17q) is not specific for pediatric PNETs, as it is also seen in leukemias and other solid tumors. However, in PNETs it may be a primary change related to tumor development and/or progression. Clinically, there was no correlation of the cytogenetic findings with histolog...Continue Reading

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Citations

Jan 1, 1996·Genes, Chromosomes & Cancer·H BlaekerS H Bigner
Sep 29, 2000·International Journal of Cancer. Journal International Du Cancer·J HermsH A Kretzschmar
Jun 1, 1992·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Sep 1, 1992·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Feb 1, 1994·Genes, Chromosomes & Cancer·J A BiegelB S Emanuel
Feb 1, 1994·Genes, Chromosomes & Cancer·U R KeesD Spagnolo
Aug 1, 1994·Genes, Chromosomes & Cancer·F MertensF Mitelman
Dec 1, 1994·Genes, Chromosomes & Cancer·Y FujiiY Hayashi
Jan 1, 1995·Journal of Neuro-oncology·S K BatraS H Bigner
Feb 1, 1994·Molecular and Chemical Neuropathology·J Q TrojanowskiV M Lee
Dec 1, 1991·Cancer Genetics and Cytogenetics·J R SawyerW M Chadduck
Jul 1, 1995·Cancer Genetics and Cytogenetics·J van EchtenW M Molenaar
Aug 1, 1994·Critical Reviews in Oncology/hematology·W M Molenaar, J Q Trojanowski
May 19, 2005·Cancer Genetics and Cytogenetics·Peter B DallasUrsula R Kees
Dec 6, 2001·Cancer Genetics and Cytogenetics·P RobertsE Sheridan
Jan 22, 2002·Cancer Genetics and Cytogenetics·Ahter Dilsad ToramanTekinalp Gelen
Oct 14, 2003·Cancer Genetics and Cytogenetics·Ella LiberzonRina Zaizov
Dec 1, 1996·Cancer Genetics and Cytogenetics·D R BettsF K Niggli
Jul 1, 1997·Cancer Genetics and Cytogenetics·C López-GinésA Llombart-Bosch
Aug 1, 1997·Cancer Genetics and Cytogenetics·M B BhattacharjeeL D Cooley
Sep 1, 1997·Cancer Genetics and Cytogenetics·S H BignerH S Friedman
Apr 18, 1998·Cancer Genetics and Cytogenetics·C OrellanaL Badía
Aug 26, 1998·Neuropathology and Applied Neurobiology·M T GiordanaE Pavanelli
Aug 15, 2002·Neuropathology and Applied Neurobiology·D Ellison
Jan 4, 1998·Journal of Pediatric Hematology/oncology·J A Biegel
May 15, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chii-Shuenn YangMing Chen
Dec 17, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·David J HolthouseUrsula R Kees
Sep 1, 1990·Brain Pathology·S H Bigner, B Vogelstein
Apr 1, 1997·Brain Pathology·L B RorkeR J Packer
Dec 18, 2008·Neuro-oncology·Hirokatsu OsawaJames T Rutka

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