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Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes

Journal of Biochemical and Molecular Toxicology

Dec 30, 2008

Pradyumna K MishraKewal Krishan Maudar

Abstract

Isocyanates, a group of low molecular weight aromatic and aliphatic compounds containing the isocyanate group (-NCO), are important raw materials with diverse industrial applications; however, pathophysiological implications resulting from occupational and accidental exposures of these ...read more

Mentioned in this Paper

Isocyanates
Guanosine
Interleukins
H2AFX gene
Annexin A5
Derivatives
Tumor Necrosis Factor-alpha
H2AFX wt Allele
Apoptosis, Intrinsic Pathway
Cell Cycle Proteins
1
26
Paper Details
References
  • References33
  • Citations26
1234
  • References33
  • Citations26
123

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Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes

Journal of Biochemical and Molecular Toxicology

Dec 30, 2008

Pradyumna K MishraKewal Krishan Maudar

PMID: 19111005

DOI: 10.1002/jbt.20260

Abstract

Isocyanates, a group of low molecular weight aromatic and aliphatic compounds containing the isocyanate group (-NCO), are important raw materials with diverse industrial applications; however, pathophysiological implications resulting from occupational and accidental exposures of these ...read more

Mentioned in this Paper

Isocyanates
Guanosine
Interleukins
H2AFX gene
Annexin A5
Derivatives
Tumor Necrosis Factor-alpha
H2AFX wt Allele
Apoptosis, Intrinsic Pathway
Cell Cycle Proteins
1
26

Similar Papers Found In These Feeds

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

DNA Damage

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic stability. Here is the latest research pertaining to DNA damage.

Related Papers

Environmental and Molecular Mutagenesis

Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells

Environmental and Molecular MutagenesisFebruary 7, 2009
Pradyumna K MishraKewal Krishan Maudar
Paper Details
References
  • References33
  • Citations26
1234
  • References33
  • Citations26
123
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