PMID: 12236704Sep 19, 2002Paper

Isoflavone-free soy protein prepared by column chromatography reduces plasma cholesterol in rats

Journal of Agricultural and Food Chemistry
Kensuke FukuiTadahisa Shimoda

Abstract

To know whether isoflavones are responsible for the hypocholesterolemic effect of soy protein, the effect on plasma cholesterol of isoflavone-free soy protein prepared by column chromatography was examined in rats. Five-week-old male Sprague-Dawley rats were fed cholesterol-enriched AIN-93G diets containing either 20% casein (CAS), 20% soy protein isolate (SPI), 20% isoflavone-free SPI (IF-SPI), 19.7% IF-SPI + 0.3% isoflavone-rich fraction (isoflavone concentrate, IC), or 20% CAS + 0.3% IC for 2 weeks. Plasma total cholesterol concentrations of rats fed SPI and IF-SPI were comparable and were significantly lower than that of rats fed CAS. The addition of IC to the CAS and IF-SPI did not influence plasma cholesterol level. Fecal steroid excretion of the three SPI groups was higher than that of the two CAS groups, whereas the addition of IC showed no effect. Thus, a significant fraction of the cholesterol-lowering effect of SPI in rats can be attributed to the protein content, but the isoflavones and other minor constituents may also play a role.

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Citations

Jun 6, 2003·Archives of Pharmacal Research·Jin Seok SookHae Soo Kwak
Aug 24, 2005·Archives of Pharmacal Research·Byung-Ju JeonHae-Soo Kwak
May 5, 2012·Journal of Agricultural and Food Chemistry·Masashi AsanomaYasuo Watanabe
Aug 2, 2003·Clinical and Experimental Pharmacology & Physiology·Hiroshi Ogawa, Satoshi Mochizuki
Dec 9, 2010·Journal of Medicinal Food·Ederlan de Souza FerreiraValdir Augusto Neves
Sep 23, 2011·Lipids in Health and Disease·Priscila G FassiniAureluce Demonte
Sep 27, 2008·Pakistan Journal of Biological Sciences : PJBS·Nikravesh Mohammad RezaBehnam-Rassouli Morteza
Dec 10, 2013·Bioscience, Biotechnology, and Biochemistry·Tatsuya MoriyamaSetsuko Todoriki
Jun 1, 2004·Bioscience, Biotechnology, and Biochemistry·Kensuke FukuiMakoto Kito
Jan 16, 2010·Molecular Nutrition & Food Research·Elena RigamontiGiulia Chiesa
Oct 26, 2016·Journal of Food Science and Technology·Swati SethiRahul K Anurag
Dec 7, 2017·Bioscience, Biotechnology, and Biochemistry·Ryoko Shimada, Kiyoshi Ebihara
Jan 5, 2005·BioFactors·Kiyoharu TakamatsuKeiko Abe
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Sep 12, 2020·Current Research in Food Science·Md Anisur Rahman Mazumder, Thottiam Vasudevan Ranganathan
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Jun 26, 2003·Journal of Agricultural and Food Chemistry·Kenneth D R Setchell, Sidney J Cole
Dec 7, 2007·Journal of Agricultural and Food Chemistry·Seong-Jun ChoCherl-Ho Lee

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