PMID: 12236704Sep 19, 2002Paper

Isoflavone-free soy protein prepared by column chromatography reduces plasma cholesterol in rats

Journal of Agricultural and Food Chemistry
Kensuke FukuiTadahisa Shimoda


To know whether isoflavones are responsible for the hypocholesterolemic effect of soy protein, the effect on plasma cholesterol of isoflavone-free soy protein prepared by column chromatography was examined in rats. Five-week-old male Sprague-Dawley rats were fed cholesterol-enriched AIN-93G diets containing either 20% casein (CAS), 20% soy protein isolate (SPI), 20% isoflavone-free SPI (IF-SPI), 19.7% IF-SPI + 0.3% isoflavone-rich fraction (isoflavone concentrate, IC), or 20% CAS + 0.3% IC for 2 weeks. Plasma total cholesterol concentrations of rats fed SPI and IF-SPI were comparable and were significantly lower than that of rats fed CAS. The addition of IC to the CAS and IF-SPI did not influence plasma cholesterol level. Fecal steroid excretion of the three SPI groups was higher than that of the two CAS groups, whereas the addition of IC showed no effect. Thus, a significant fraction of the cholesterol-lowering effect of SPI in rats can be attributed to the protein content, but the isoflavones and other minor constituents may also play a role.


Oct 24, 1985·The New England Journal of Medicine·M J StampferC H Hennekens
Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Jan 1, 1994·Nutrition and Cancer·M J MessinaS Barnes
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S AnthonyJ D Wagner
Dec 16, 1998·The American Journal of Clinical Nutrition·S M PotterJ W Erdman
Jan 23, 1999·Annals of Nutrition & Metabolism·L NogowskiK W Nowak

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