Isoflavone supplementation reduces DNA oxidative damage and increases O-β-N-acetyl-D-glucosaminidase activity in healthy women

Nutrition Research
Daniela ErbaLuca Massaccesi

Abstract

Phenolic compounds are believed to boost the human antioxidant defense system and health; therefore, the aim of this research was to investigate the hypothesis that soy isoflavones (IFs) provide antioxidant protection in healthy women by evaluating DNA resistance to oxidative damage and O-β-N-acetyl-D-glucosaminidase (OGA) activity. An IF supplement (80 mg/d) was given to 9 postmenopausal women and 13 young women for 6 months and then stopped up to the 14th month. The women were allowed to consume their normal diet. Blood samples were collected at the beginning of the study after 2, 4, and 6 months and then at the 8th and 14th months. Plasma concentrations of genistein and daidzein, total antioxidant capacity, plasma vitamin status, markers of oxidative stress (red blood cell membrane fluidity, activity of the red blood cell cytosolic enzyme OGA and lymphocyte DNA susceptibility to oxidative stress), and serum lipid profile were analyzed. Analysis of variance for repeated measures was used for statistical analysis. Plasma concentrations of IFs rose significantly during the supplementation period, and plasma total antioxidant capacity increased in young women; membrane fluidity and OGA activity increased, and DNA oxidative damag...Continue Reading

References

Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·H WeiY Wang
Jan 6, 2000·Archives of Biochemistry and Biophysics·A AroraG M Strasburg
Dec 8, 2004·Archives of Biochemistry and Biophysics·P FotiG Testolin
Feb 8, 2006·Mechanisms of Ageing and Development·L MassaccesiGiancarlo Goi
Feb 17, 2006·European Journal of Clinical Nutrition·N VédrineC Manach
Apr 24, 2007·Journal of Applied Microbiology·E J Woodmansey
Oct 29, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Angela SpadafrancaGiulio Testolin

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Citations

Nov 21, 2014·Journal of Clinical Biochemistry and Nutrition·Koufuchi RyoIchiro Saito
Oct 1, 2014·Drug and Chemical Toxicology·Ludymila Furtado CantanhêdeSilma Regina Ferreira Pereira
Oct 26, 2013·Climacteric : the Journal of the International Menopause Society·C P TeixeiraA F Carbonel
Dec 17, 2016·Molecular Nutrition & Food Research·Varinderpal S DhillonMichael Fenech
May 24, 2013·International Journal of Molecular Sciences·Isabella SaviniLuciana Avigliano
Oct 12, 2018·Revista da Associação Médica Brasileira·Adriana Aparecida Ferraz CarbonelEdmund Chada Baracat
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Mar 7, 2021·International Journal of Molecular Sciences·Israel Pérez-TorresVerónica Guarner-Lans
Apr 8, 2021·Journal of Toxicology and Environmental Health. Part a·Pollyanna Francielli De OliveiraDenise Crispim Tavares

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