Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats

Anesthesia and Analgesia
P M PatelM Watson

Abstract

Repetitive transient ischemic depolarizations (IDs) during focal cerebral ischemia are thought to contribute to ischemic damage. Isoflurane and pentobarbital reduce injury (versus the nonanesthetized state) after focal cerebral ischemia. The mechanism by which these drugs reduce injury is not known. This protective effect might be mediated by a reduction in the number of IDs. We measured the frequency of IDs during focal cerebral ischemia in animals anesthetized with isoflurane or pentobarbital and compared it with that in N2O/fentanyl anesthetized animals and in animals in which the N-methyl-D-aspartate receptor antagonist MK801 (dizocilpine) was given. Focal cerebral ischemia was induced by the occlusion of the middle cerebral artery for a period of 2 h. Cortical infarct volumes were determined after 3 h of reperfusion by image analysis of 2,3,5-triphenyl tetrazolium-stained coronal brain sections. The infarct volume was significantly greater in the N2O/fentanyl group than in the other three groups. Infarct volumes in the isoflurane, pentobarbital, and MK801 groups were similar. The frequency of IDs was significantly greater in the N2O/fentanyl group than in the other three groups, and was the least in the MK801 group. There ...Continue Reading

References

Nov 1, 1976·British Journal of Pharmacology·C D Richards, J C Smaje
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GillH Hagberg
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IijimaK A Hossmann
Jan 1, 1991·Annals of the New York Academy of Sciences·E PuilK G Baimbridge
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Jan 1, 1991·Annals of the New York Academy of Sciences·J Yang, C F Zorumski
Sep 1, 1986·Neuroscience·F N Quandt, B A MacVicar
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Nedergaard, J Astrup
Mar 1, 1983·British Journal of Anaesthesia·C D Richards
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackK A Hossmann
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Nedergaard, A J Hansen
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R G GiffardD W Choi
Apr 1, 1993·Anesthesiology·D L TanelianM B MacIver
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Q ChenH Chen
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackB D Watson
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E BuschK A Hossmann
Apr 1, 1992·Journal of Neurosurgical Anesthesiology·D J ColeS Marcantonio

❮ Previous
Next ❯

Citations

Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sandrine LopezXavier Capdevila
Sep 21, 2000·Journal of Neuroscience Methods·A RozzaL Montalbetti
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Robert D SandersMervyn Maze
Jun 26, 2014·Brain Sciences·Sunny Chiao, Zhiyi Zuo
Nov 1, 2011·Acta Neurologica Scandinavica·H BolouriA Hamberger
Jan 15, 2005·Brain Research·Alexandra CorralesEsperanza Recio-Pinto
Feb 27, 2013·Revista brasileira de anestesiologia·Rogean Rodrigues NunesSara Lúcia Cavalcante
Feb 22, 2012·Toxicology·Thomas W SawyerRobert Frew
Jan 2, 2007·Journal of Neuroscience Methods·Kathrin BaldaufKlaus G Reymann
May 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David W HowellsMalcolm R Macleod
Oct 19, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideto KitanoStephanie J Murphy
Nov 24, 2004·Journal of Neurosurgical Anesthesiology·David S Warner
Feb 7, 2009·Stroke; a Journal of Cerebral Circulation·Ron KooijmanJacques De Keyser
Oct 3, 2006·Current Opinion in Anaesthesiology·D K Menon, A C Summors
Feb 17, 2000·The New England Journal of Medicine·C M Muth, E S Shank

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.