PMID: 2493751Mar 1, 1989Paper

Isoflurane attenuates baroreflex control of heart rate in human neonates

Anesthesiology
I MuratC Saint-Maurice

Abstract

Clinical studies have suggested that baroreflex regulation of heart rate may be more affected by inhalational anesthetics in human neonates or young animals than in adults. To test this hypothesis, baroreceptor reflex control of heart rate was studied in eight neonates during administration of 1 MAC isoflurane. The neonates were hemodynamically stable and their lungs were mechanically ventilated. No other anesthetic was used. Mean (+/- SD) corrected gestational age was 39.4 +/- 2.0 weeks and mean weight was 2,710 +/- 430 g. The pressor response was tested with the use of phenylephrine and the depressor response with nitroglycerin. Changes in heart rate (R-R interval) were plotted against the changes in systolic arterial pressure, and the slope of the linear portion of this relationship was used to define the baroreflex response. Both baroresponses measured in awake neonates varied widely between patients. With administration of approximately 1 MAC isoflurane, the pretest mean systolic arterial pressure decreased by about 30% (P less than 0.001), whereas mean heart rate values remained unchanged compared with control awake values. During isoflurane administration, the mean (+/- SD) pressor response decreased to 23% of control aw...Continue Reading

Citations

Jan 1, 1993·Brain Research Bulletin·A L CurtisR J Valentino
Jan 7, 1998·Anesthesiology·V C Baum, B W Palmisano
Jul 30, 2005·The Journal of Physiology·Peter AndriessenCarlos E Blanco
May 24, 2011·Experimental Physiology·Lindsea C BoothLaura Bennet
Jul 24, 2004·Seminars in Pediatric Surgery·Simon C HillierElena Brasoveanu
Feb 1, 1993·Early Human Development·P S BucknerN N Finer
Nov 20, 1998·Seminars in Perinatology·D J Mellor, J Lerman

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