Isoflurane does not further impair microvascular vasomotion in a rat model of subarachnoid hemorrhage

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Kyung W ParkFrank W Sellke

Abstract

Since isoflurane is known to attenuate endothelium-dependent dilation (EDD) in normal cerebral arterioles, we examined whether the anesthetic has a similar effect and further impairs EDD in vessels exposed to SAH. Autologous blood was introduced in the subarachnoid space and the parietal lobe harvested. Control animals were sacrificed without introduction of blood. The response of microvessles to the endothelium-dependent dilator adenosine diphosphate (ADP) 10(-9)-10(-4) M, the endothelium-independent dilator nitroprusside 10(-9)-10(-4) M, and ET-1 10(-13)-10(-8) M was measured by videomicroscopy in the presence of 0-2 minimum alveolar concentration (MAC) of isoflurane. Isoflurane attenuated EDD to ADP in control vessels [66 +/- 5% (control) vs 27 +/- 11% (2 MAC) dilation to ADP 10(-4) M, P < 0.05]. Although SAH was associated with reduced dilation to ADP, exposure to isoflurane did not further impair dilation to ADP after SAH [26 +/- 3% (SAH) vs 21 +/- 5% (SAH/2 MAC) dilation to ADP 10(-4) M, P = NS]. Dilation to nitroprusside was not affected by isoflurane or SAH. Constriction to ET-1 was reduced by 2 MAC of isoflurane [21 +/- 1% (control) vs 13 +/- 5% (2 MAC) constriction to ET-1 10(-8) M, P < 0.05], but not by 1 MAC of isof...Continue Reading

References

Jul 20, 1978·The New England Journal of Medicine·T M Sundt, J P Whisnant
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T D HansenL J Vust
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·T J DelgadoN A Svendgaard
Jul 1, 1974·Anesthesiology·T S VitezE I Eger
Jan 1, 1968·Journal of Neurosurgery·B W BrawleyW A Kelly
Nov 1, 1993·Anesthesia and Analgesia·R W McPhersonR J Traystman
Mar 3, 1998·Neurosurgery·J B BedersonP Vallabhajosyula
Jul 21, 1999·Kidney International. Supplement·J A JolesT J Rabelink
Sep 15, 1999·Anesthesiology·B F MattaA C Summors
Dec 11, 1999·Japanese Journal of Pharmacology·K TakahashiT Iwasaki
Feb 17, 2000·The New England Journal of Medicine·R HambrechtG Schuler
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·K W ParkF W Sellke

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Citations

Feb 11, 2014·Translational Stroke Research·Michael K Tso, R Loch Macdonald
May 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Mauro OddoGiuseppe Citerio
Dec 18, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matilde BalbiNikolaus Plesnila
Sep 15, 2005·Journal of Applied Physiology·Jennifer Rogers, Don D Sheriff
Jun 24, 2021·Journal of Neurochemistry·Jiru ZhouHua Feng

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