Isoflurane in the presence or absence of surgery increases hippocampal cytokines associated with memory deficits and responses to brain injury in rats

Behavioural Brain Research
Jennifer K CallawayColin F Royse

Abstract

Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2-4h of isoflurane anesthetic without surgical trauma can also impair cognitive function. We aimed to determine cytokine changes over time following isoflurane exposure in the presence and absence of surgery and examine subsequent cognitive function. Male rats were exposed to isoflurane (1.8%, 4h) with or without laparotomy or control conditions and tested in a contextual fear conditioning paradigm 8 days later. On day 9 rats were perfused, serum and hippocampal samples were collected and 24 cytokines were analysed. Groups of rats exposed as above were killed 6 or 48h after isoflurane exposure to examine early cytokine changes. Isoflurane exposure resulted in significantly less freezing in the contextual fear conditioning test (F(2,31)=6.11, P=0.006) and addition of laparotomy caused no further deficits (P>0.05). At 6h post isoflurane exposure an immunosuppressive response was observed in the serum while hippocampal cytokines were largely unchanged. These finding suggest isoflurane alone causes inflammatory chan...Continue Reading

References

Aug 1, 1992·The British Journal of Surgery·R J BaigrieP J Morris
May 1, 1992·Science·J J Kim, M S Fanselow
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ido YatsivPhilip F Stahel
Mar 26, 2003·Anesthesia and Analgesia·Deborah J CulleyGregory Crosby
Jul 26, 2005·Trends in Immunology·Britta Engelhardt, Richard M Ransohoff
Oct 12, 2005·Current Psychiatry Reports·Alan D Valentine, Christina A Meyers
Jan 16, 2007·Nature Reviews. Immunology·V Hugh PerryClive Holmes
Jan 18, 2007·British Journal of Anaesthesia·R A KumarA R Wilkes
Nov 3, 2007·Psychoneuroendocrinology·Inbal GoshenRaz Yirmiya
Aug 8, 2008·Journal of Anesthesia·Shin Kurosawa, Masato Kato
Nov 11, 2008·Neuroscience and Biobehavioral Reviews·J McAfoose, B T Baune
Sep 5, 2009·Behavioural Brain Research·Takahiro YaguchiTomoyuki Nishizaki
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kai DiederichWolf-Rüdiger Schäbitz
Feb 2, 2010·Journal of Neuroinflammation·Silvia AlboniBruno Conti
May 5, 2010·The Journal of Experimental Medicine·Noël C DereckiJonathan Kipnis
May 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Niccolò TerrandoMervyn Maze
Aug 10, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xue-Zhao CaoWen-Fei Tan
Oct 26, 2010·Brain, Behavior, and Immunity·Raz Yirmiya, Inbal Goshen
May 18, 2011·Neuroscience Letters·António Rei FidalgoDaqing Ma
Dec 23, 2011·Annals of Neurology·Niccolò TerrandoMervyn Maze
Feb 22, 2012·European Journal of Anaesthesiology·Jennifer K CallawayColin F Royse
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruth M BarrientosSteven F Maier

❮ Previous
Next ❯

Citations

Oct 22, 2016·Journal of Neurosurgical Anesthesiology·William M JacksonCyrus D Mintz
Sep 12, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ana Lucía Rodríguez-PereaPaula Andrea Velilla Hernández
Jan 25, 2017·Behavioural Brain Research·Chengmei ShiXiangyang Guo
Jun 26, 2018·The Journal of International Medical Research·Ji Won Choi, Byung Seop Shin
Dec 29, 2019·BMC Anesthesiology·Jillian C Belrose, Ruediger R Noppens
Mar 20, 2019·Journal of Neuroendocrinology·Florent PittetBenjamin C Nephew
Nov 17, 2020·Frontiers in Neuroscience·Jenny L KimHeather A Cameron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.