Isoflurane induces cognitive deficits in the Morris water maze task in rats

European Journal of Anaesthesiology
Jennifer K CallawayColin F Royse

Abstract

Postoperative cognitive dysfunction has been reported in young, middle-aged and elderly patients with greater incidence with increasing age. Neurocognitive deficits are associated with anaesthetic exposure in aged rodents but in younger adult animals the findings are inconsistent and in middle-aged animals they are unknown. We aimed to compare the effects of moderate duration isoflurane anaesthesia in 100% oxygen on Morris water maze performance in young adult and middle-aged rats. We hypothesised that isoflurane would have greater effects on learning and memory in middle-aged compared with young rats. Young adult (3 months, n = 25) and middle-aged (12 months, n = 20) male Sprague Dawley rats were assigned randomly to isoflurane exposure (1 minimum alveolar concentration, 4 h) or control conditions. Spatial learning (acquisition phase) and memory (probe trial) were tested in the Morris water maze 1 week after exposure. Middle-aged rats were retested in the probe trial 4 weeks after exposure for long-term memory retention. Latency to locate the hidden platform and time spent in the platform quadrant were compared between ages and treatments. Isoflurane did not affect acquisition of the water maze task in either age group. Isoflu...Continue Reading

References

Nov 1, 1989·Neurobiology of Aging·M Gallagher, R D Burwell
Sep 1, 1988·Neurobiology of Aging·M Gallagher, M A Pelleymounter
May 1, 1984·Journal of Neuroscience Methods·R Morris
Feb 24, 2001·Acta Anaesthesiologica Scandinavica·L S RasmussenUNKNOWN ISPOCD group. The International Study of Postoperative Cognitive Dysfunction
Jul 24, 2001·Anesthesiology·W SimonG Rammes
Mar 26, 2003·Anesthesia and Analgesia·Deborah J CulleyGregory Crosby
Aug 24, 2005·Anesthesia and Analgesia·Lisa Wise-FaberowskiDavid S Warner
Oct 26, 2005·Anesthesia and Analgesia·Catherine CrosbyGregory Crosby
Jan 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zhongcong XieRudolph E Tanzi
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhongcong XieRudolph E Tanzi
Dec 25, 2007·Anesthesiology·Terri G MonkJoachim S Gravenstein
Dec 25, 2007·Journal of Neurosurgical Anesthesiology·Stephen A JohnsonJohn W Olney
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guohua ZhangZhongcong Xie
Apr 29, 2009·Behavioural Brain Research·Nigel C JonesMichael R Salzberg
Sep 22, 2009·European Journal of Pharmacology·Rainer HasenederGerhard Rammes
Jan 14, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Changlian ZhuKlas Blomgren
Oct 12, 2010·Neurochemistry International·Tobias Horn, Jochen Klein
Mar 8, 2011·Cell·Akinobu SuzukiCristina M Alberini

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Citations

Aug 21, 2012·Anesthesiology Clinics·Ansgar M BrambrinkJeffrey R Kirsch
Feb 28, 2016·Paediatric Anaesthesia·Elvan OcmenNecati Gokmen
Mar 16, 2016·Journal of Neuroscience Methods·Folabomi A OladosuAndrea G Nackley
Aug 8, 2013·Annals of Neurology·Rebekah MannixMichael Whalen
Apr 5, 2013·Fundamental & Clinical Pharmacology·Alper KilicaslanEsra Nurullahoglu Atalik
May 20, 2016·Molecular Neurobiology·Cheng NiZhongcong Xie
Jan 25, 2017·Behavioural Brain Research·Chengmei ShiXiangyang Guo
Aug 2, 2018·Hippocampus·Marco ContrerasJean-Marc Fellous
May 28, 2019·Journal of Cellular Physiology·Wenqian YangZhigang Cheng
Jan 15, 2013·Current Protocols in Neuroscience·Angela M YarnellNeil E Grunberg
Sep 23, 2016·Journal of Neurosurgical Anesthesiology·Timothy P DeYoungWilliam A Kofke
Feb 14, 2013·Experimental and Therapeutic Medicine·Jingjun ChenXueping Han
Jan 31, 2020·Frontiers in Behavioral Neuroscience·María RodríguezMarco Contreras
Aug 22, 2012·European Journal of Anaesthesiology·Stefan Braunecker, Jochen Hinkelbein
Feb 26, 2013·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Aug 22, 2012·European Journal of Anaesthesiology·Jennifer K CallawayColin F Royse
Jan 14, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L SegarJustin L Grobe
Jan 20, 2021·Neurotoxicology and Teratology·Timothy J FlaniganSherry A Ferguson

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