Isoflurane modulates genomic expression in rat amygdala

Anesthesia and Analgesia
Ira J RampilAchim H Bell

Abstract

General anesthesia, at a minimum, provides amnesia and unresponsiveness. Although anesthetics have many modulatory effects on neuronal ionophore protein complexes, it is not clear that the resulting electrophysiologic changes are the sole mechanisms of clinical anesthetic action. Cells respond to environmental changes in several ways, including alterations in DNA transcription leading to changes in the cell's proteins. We sought to expose the changes in global genomic expression, seeking potential targets involved in the processes of anesthetic-induced amnesia, and persistent long-term side effects of general anesthesia, including nausea and postoperative cognitive decline. Using Affymetrix GeneChips, we surveyed changes in expression across the entire expressed genome of Sprague-Dawley rat (n = 10 baseline, n = 6 isoflurane) basolateral amygdala 6 h after exposure to 15 min of 2% (1.4 MAC) isoflurane. Isoflurane administration was associated with altered expression in 269 unique genes possessing functional annotation. Affected genes were related to DNA transcription, protein synthesis, metabolism, signaling cascades, cytoskeletal structural proteins, and neural-specific proteins, among others. Even brief exposure to isoflurane...Continue Reading

References

Jul 1, 1990·Environmental Health Perspectives·N P Franks, W R Lieb
Mar 15, 1995·Biochemical Pharmacology·D C MartinR S Aronstam
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M C SanguinettiM T Keating
Jan 19, 1999·Annual Review of Cell and Developmental Biology·N K Gray, M Wickens
Oct 26, 1999·Trends in Genetics : TIG·M Mayford, E R Kandel
Feb 28, 2001·The Journal of Molecular Diagnostics : JMD·M S RajeevanE R Unger
Mar 22, 2002·The Journal of Biological Chemistry·Edwin J WeeberWilliam J Craigen
Feb 25, 2003·Current Topics in Microbiology and Immunology·Q Feng, Y Zhang
Mar 18, 2003·Molecular and Cellular Biology·Masanobu MoritaYoshiaki Fujii-Kuriyama
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabina KupershmidtJeffrey R Balser
Apr 22, 2004·Journal of Neuropathology and Experimental Neurology·E DalfóI Ferrer
Jun 24, 2004·Best Practice & Research. Clinical Anaesthesiology·Christine E SchneemilchUte Bank
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gabriela LavezzariKatherine W Roche
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christina I PetersenJeffrey R Balser
Aug 7, 2004·The Journal of Biological Chemistry·Nashaat Z GergesJosé A Esteban
Sep 21, 2004·Nature Reviews. Neuroscience·Eunjoon Kim, Morgan Sheng
Sep 28, 2004·Science·Mikyoung ParkMichael D Ehlers
Dec 21, 2004·Nucleic Acids Research·Donna MaglottTatiana Tatusova
May 25, 2005·Molecular and Cellular Neurosciences·Stefano AlberiDominique Muller

❮ Previous
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Citations

Feb 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor PonomarevMichael S Fanselow
Jul 3, 2010·Redox Report : Communications in Free Radical Research·H SoneT Fukuda
Mar 5, 2009·Radiation and Environmental Biophysics·Onarae V RiceSamuel J Gatley
Jan 23, 2016·Frontiers in Behavioral Neuroscience·Kristopher M BuntingAlmira Vazdarjanova
Jul 13, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Junxia X TangMaryellen F Eckenhoff
Nov 1, 2008·The European Journal of Neuroscience·Samuel TétraultFlorin Amzica
Jul 22, 2014·Acta Anaesthesiologica Scandinavica·T PeknyM Pekny
Sep 19, 2006·European Journal of Pharmacology·Deborah J CulleyGregory Crosby
Aug 10, 2016·BMC Genomics·Isain ZapataCarlos E Alvarez
Sep 23, 2008·Anesthesia and Analgesia·In Ho LeeGregory Crosby
Oct 28, 2009·Anesthesiology·Lixin LiuMario J Rebecchi
Feb 2, 2010·Journal of Neurosurgical Anesthesiology·Armin KalenkaRobert E Feldmann
Apr 26, 2007·Anesthesia and Analgesia·Jonathan Z PanMaryellen F Eckenhoff
Apr 26, 2007·Anesthesia and Analgesia·Armin KalenkaMartin H Maurer
May 28, 2019·Journal of Cellular Physiology·Wenqian YangZhigang Cheng
Jul 27, 2020·Environmental Epigenetics·Jill Escher, La Donna Ford
Dec 2, 2010·Sleep·Aaron B NelsonChiara Cirelli

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