Isoflurane modulates neuronal excitability of the nucleus reticularis thalami in vitro.

Annals of the New York Academy of Sciences
Pavle M Joksovic, Slobodan M Todorovic

Abstract

The thalamus has a key function in processing sensory information, sleep, and cognition. We examined the effects of a common volatile anesthetic, isoflurane, on modulation of neuronal excitability in reticular thalamic nucleus (nRT) in intact brain slices from immature rats. In current-clamp recordings, isoflurane (300-600 micromol/L) consistently depolarized membrane potential, decreased input resistance, and inhibited both rebound burst firing and tonic spike firing modes of nRT neurons. The isoflurane-induced depolarization persisted not only in the presence of tetrodotoxin, but after replacement of Ca(2+) with Ba(2+) ions in external solution; it was abolished by partial replacement of extracellular Na(+) ions with N-methyl-D-glucamine. In voltage-clamp recordings, we found that isoflurane slowed recovery from inactivation of T-type Ca(2+) current. Thus, at clinically relevant concentrations, isoflurane inhibits neuronal excitability of nRT neurons in developing brain via multiple ion channels. Inhibition of the neuronal excitability of thalamic cells may contribute to impairment of sensory information transfer in the thalamocortical network by general anesthetics. The findings may be important for understanding cellular me...Continue Reading

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Jun 23, 2007·Anesthesiology·Wei OuYang, Hugh C Hemmings

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Citations

Sep 14, 2011·Pflügers Archiv : European journal of physiology·Philippe CoulonHans-Christian Pape
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·François DavidVincenzo Crunelli
Aug 24, 2011·Issues in Mental Health Nursing·Jacquelyn H Flaskerud
Sep 28, 2016·ELife·Susana S CorreiaKi A Goosens
Jun 2, 2012·Inquiry : a Journal of Medical Care Organization, Provision and Financing·Alan C Monheit
Feb 27, 2013·Current Anesthesiology Reports·Matthew T Scharf, Max B Kelz
Aug 10, 2017·Frontiers in Systems Neuroscience·Kevin D AllowayGlenn D R Watson

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