Isoflurane therapy for severe refractory status asthmaticus in children.

Intensive Care Medicine
Venkat ShankarJayant K Deshpande

Abstract

To describe the use of inhaled isoflurane in a series of children with life-threatening asthma. Retrospective case series. Pediatric intensive care unit of a tertiary-care children's hospital. Ten children ranging in age from 1 to 16 years with 11 episodes of severe asthma requiring invasive mechanical ventilation in the pediatric intensive care unit over a 5-year period. Isoflurane resulted in an improvement in arterial pH and a reduction in partial pressure of arterial carbon dioxide (PaCO(2)) in all the 11 instances. This effect was sustained in 10 cases and led to clinical improvement and rapid weaning from mechanical ventilation. One child failed to show sustained response and was placed on veno-venous extracorporeal membrane oxygenation. One child died secondary to anoxic brain injury sustained prior to hospitalization. Hypotension was the major side effect, and occurred in 8 children necessitating vasopressor support. Isoflurane improves arterial pH and reduces partial pressure of arterial carbon dioxide in mechanically ventilated children with life-threatening status asthmaticus who are not responsive to conventional management.

References

Mar 1, 1991·British Journal of Anaesthesia·J D OatesG D Murray
Jun 1, 1988·Anaesthesia·S RevellN Soni
Sep 1, 1986·Critical Care Medicine·M I BiermanF L Glauser
Feb 1, 1987·Anesthesia and Analgesia·S M ParnassL J Segil
Jul 1, 1995·Pediatric Pulmonology·A J MartinP M Yellowlees
May 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A BestP Murphy
Jul 1, 1997·Critical Care Medicine·G Reyes
Jun 1, 1997·Acta Paediatrica Japonica; Overseas Edition·T MiyagiT Miike
Jun 12, 1998·Archives of Disease in Childhood·M RiceI A Murdoch
Jan 20, 2000·Respiratory Care Clinics of North America·K Sabato, J H Hanson
Jun 5, 2001·Pediatric Pulmonology·K MalmströmK Juntunen-Backman
Aug 8, 2002·Pediatrics·Lara J Akinbami, Kenneth C Schoendorf
Jun 5, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Olugbenga A. AkingbolaRobert L. Hopkins
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·D S WheelerW B Poss

❮ Previous
Next ❯

Citations

Nov 14, 2007·Der Anaesthesist·C SirtlA Meiser
Oct 27, 2006·Intensive Care Medicine·Ritesh Agarwal, Alok Nath
Jul 26, 2013·British Journal of Anaesthesia·D SchutteJ Lemson
Feb 27, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Danton S CharSusan L Bratton
May 8, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christopher L Carroll
Mar 16, 2012·Respiratory Care·David A TurnerScot T Bateman
Jul 6, 2014·Expert Review of Respiratory Medicine·Judith J M WongKyle J Rehder
Jun 3, 2015·Chest·James Leatherman
Apr 13, 2013·Paediatric Respiratory Reviews·Muriel KoninckxMatthijs de Hoog
Mar 30, 2013·Critical Care Clinics·Christopher L Carroll, Kathleen A Sala
Mar 30, 2013·Critical Care Clinics·Ryan Wilkes, Robert C Tasker
Aug 11, 2012·Mayo Clinic Proceedings·Christopher M WittichWilliam L Lanier
Mar 22, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Martha M Rumore
Aug 25, 2009·The Journal of Emergency Medicine·Barry BrennerAntoine Kazzi
Jan 9, 2016·Drug Discovery Today. Disease Models·Jarred R MondoñedoDavid W Kaczka
Mar 31, 2009·Journal of Critical Care·Jens SoukupJesco Kompardt
Mar 28, 2008·Paediatric Anaesthesia·Kazuhiro WatanabeMakoto Tanaka
Jan 13, 2015·Paediatric Anaesthesia·Sabrina Carrié, Thomas Anthony Anderson
Aug 12, 2014·Journal of Critical Care·Alberto MedinaEmili Ibiza-Palacios
May 31, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAlberto Zangrillo
Jul 1, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alba PalaciosJesus Lopez-Herce
Aug 18, 2016·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M Laufenberg, T Schneider
Sep 5, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lorry R FrankelUNKNOWN Voting Panel
May 21, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Jarred R MondoñedoDavid W Kaczka
Dec 3, 2010·Paediatric Anaesthesia·Andrew R Wolf, Lara Jackman
Oct 15, 2014·Current Opinion in Pediatrics·Robert C Tasker, Sally H Vitali
Nov 3, 2020·Critical Care Explorations·Armin Niklas FlinspachElisabeth Hannah Adam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Paediatrica Japonica; Overseas Edition
T MiyagiT Miike
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
D S WheelerW B Poss
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Joseph D Tobias
© 2022 Meta ULC. All rights reserved