Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets.

Intensive Care Medicine
Harald SchubertReinhard Bauer

Abstract

There is compelling evidence that interference of various anesthetics with synaptic functions and stress-provoking procedures during critical periods of brain maturation results in increased neuroapoptotic cell death. The hypothesis is that adverse intrauterine environmental conditions leading to intrauterine growth restriction (IUGR) with altered brain development may result in enhanced susceptibility to developmental anesthetic neurotoxicity. This was a prospective, randomized, blinded animal study performed in a university laboratory involving 20 normal-weight (NW) and 19 IUGR newborn piglets. General inhalation anesthesia with isoflurane and nitrous oxide at clinically comparable dosages were administered for about 10 h. Surgical and monitoring procedures were accompanied by appropriate stage of general anesthesia. Resulting effects on developmental anesthetic and stress-induced neurotoxicity were assessed by estimation of apoptotic rates in untreated piglets and piglets after 10-h general anesthesia with MAC 1.0 isoflurane in 70 % nitrous oxide and 30 % oxygen. IUGR piglets exposed to different levels of isoflurane inhalation exhibited a significant increased apoptosis rate (TUNEL-positive neuronal cells) compared to NW an...Continue Reading

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Apr 2, 2013·British Journal of Anaesthesia·R D SandersD Ma
Jan 17, 2014·British Journal of Anaesthesia·M Perouansky
Oct 29, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mervyn Maze
Apr 18, 2013·Anesthesiology·Hemmen SabirMarianne Thoresen
Jan 6, 2021·Pharmaceutics·Miriam AyusoSteven Van Cruchten

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