PMID: 12763893May 24, 2003Paper

Isoform-specific regulation of Na+,K+-ATPase endocytosis and recruitment to the plasma membrane

Annals of the New York Academy of Sciences
Vera Lucas TeixeiraA M Bertorello

Abstract

The Na(+),K(+)-ATPase traffics between the plasma membrane and intracellular compartments in response to acute changes in membrane receptor activation. These effects are accomplished by a time-dependent interaction of the Na(+),K(+)-ATPase alpha-subunit with specific intracellular signaling molecules either at the plasma membrane (endocytosis) or at the endosome's membranes (recruitment). Most of these studies have been performed in rat renal epithelial cells in which only the alpha(1) isoenzyme is present. Studies in neurons from the neostriatum in which all three alpha-subunit isoforms are present indicate that neurotransmitter-dependent regulation of Na(+),K(+)-ATPase activity displays isoform specificity and also suggest a more complex organization of the intracellular signaling networks controlling Na(+),K(+)-ATPase traffic in mammalian cells.

References

Apr 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·A AperiaP Greengard
Apr 1, 1991·Cellular and Molecular Neurobiology·V HieberM Mata
May 1, 1986·Journal of Neuroscience Methods·A R Kay, R K Wong
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y G KwonA C Nairn
Nov 5, 1997·Current Opinion in Nephrology and Hypertension·K Geering
May 16, 1998·The Journal of Biological Chemistry·A V ChibalinA M Bertorello
Mar 13, 1999·The Journal of Biological Chemistry·H B HuangA C Nairn
May 5, 1999·The Journal of Membrane Biology·A L WooJ B Lingrel
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·G A YudowskiA M Bertorello
Jan 18, 2002·The Journal of Biological Chemistry·Riad EfendievCarlos H Pedemonte
Feb 23, 2002·The Journal of Biological Chemistry·Stefania Cotta DonéAlejandro M Bertorello
Dec 6, 2002·British Journal of Pharmacology·Claudia E BuduCarlos H Pedemonte

❮ Previous
Next ❯

Citations

Feb 8, 2006·Ethical Theory and Moral Practice : an International Forum·Bernard E Rollin
Nov 1, 2007·Journal of Bioenergetics and Biomembranes·Emilia LecuonaJacob I Sznajder
Nov 6, 2008·The Journal of Biological Chemistry·Lisa A HazelwoodDavid R Sibley
Sep 24, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Humberto E TrejoJacob I Sznajder
Apr 24, 2010·FEBS Letters·Hanne PoulsenPoul Nissen
Dec 22, 2007·Prostaglandins & Other Lipid Mediators·Antoine T Chalfoun, Sawsan Ibrahim Kreydiyyeh
Mar 15, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·N N MendonçaR P M Furriel
Jun 8, 2007·American Journal of Physiology. Cell Physiology·Tomer FeldmannHaim Rosen
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Angel R CinelliCarlos H Pedemonte
Oct 27, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emilia LecuonaJacob I Sznajder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.