Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Systemic Lupus Erythematosus-like Disease in a Murine Model

Journal of Agricultural and Food Chemistry
Wei LiQun Wei

Abstract

Isogarcinol is a new immunosuppressant that we extracted from Garcinia mangostana L. In the present study, we elucidate its beneficial effect in chronic graft-versus-host disease (cGVHD) in mice -- a model for systemic lupus erythematosus (SLE) in human. The oral administration of 60 mg/kg isogarcinol significantly reduced proteinuria, corrected the abnormal serum biochemical indicator, and decreased the amount of serum antibodies and lowered the renal histopathology score. In addition, isogarcinol alleviated the abnormal activation of CD4 T cells and decreased the expression of inflammatory genes and cytokines in the kidneys and peritoneal macrophages. The mechanism of action of isogarcinol is associated with downregulation of CD4 T cells and inflammatory effects. Therefore, we believe that isogarcinol may be a potential therapeutic drug candidate for future treatment of SLE.

References

Jan 1, 1988·European Journal of Immunology·R C KuppersN R Rose
Nov 18, 2000·Journal of the National Cancer Institute·D FeskanichG A Colditz
Mar 22, 2002·Nature Reviews. Immunology·M J ShlomchikM J Mamula
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miho SasakiShigeru Fujita
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas J LangCharles S Via
Oct 7, 2005·Journal of the American Society of Nephrology : JASN·Scott E WenderferMichael C Braun
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Hyun-Ah JungA Douglas Kinghorn
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Waye Chu, Ronald E Gress
Aug 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Pedraza-ChaverriJazmin M Pérez-Rojas
Oct 8, 2009·Journal of Agricultural and Food Chemistry·Miwako KondoBoxin Ou
Jun 19, 2012·Journal of Autoimmunity·Robert A Eisenberg, Charles S Via
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel J PerryLaurence Morel
Jan 11, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kelli P MacDonaldPavan Reddy
Jun 21, 2013·PloS One·Juren CenQun Wei
Feb 13, 2015·Science Translational Medicine·Yiming YinLaurence Morel

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