Jun 5, 1999

Isolate resistance of Blastocystis hominis to metronidazole

Tropical Medicine & International Health : TM & IH
K HareshS Saminathan

Abstract

Isolates of Blastocystis hominis from infected immigrant workers from Indonesia, Bangladesh and infected individuals from Singapore and Malaysia were assessed for growth pattern and degree of resistance to different concentrations of metronidazole. Viability of the cells was assessed using eosin-brillian cresyl blue which stained viable cells green and nonviable cells red. The Bangladeshi and Singaporean isolates were nonviable even at the lowest concentration of 0.01 mg/ml, whereas 40% of the initial inoculum of parasites from the Indonesian isolate at day one were still viable in cultures with 1.0 mg/ml metronidazole. The study shows that isolates of B. hominis of different geographical origin have different levels of resistance to metronidazole. The search for more effective drugs to eliminate th parasite appears inevitable, especially since surviving parasites from metronidazole cultures show greater ability to multiply in subcultures than controls.

  • References9
  • Citations42

References

Mentioned in this Paper

Cell Growth Pattern
Labor Migration
Eosine Yellowish
Isolate compound
Feces
Drug Resistance
Microbicides
Eosinum, eosin, Homeopathic preparation
Streak Plate Count
Blastocystis hominis (organism)

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

The Journal of Antimicrobial Chemotherapy
L A Dunn, P F Boreham
Journal of Clinical Microbiology
M J Lee
Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
K G Kukoschke, H E Müller
© 2020 Meta ULC. All rights reserved