Isolated α-turn and incipient γ-helix

Chemical Science
Fatemeh M MirWilliam D Lubell

Abstract

The unique abilities of homo-oligo-adamantyl peptides to adopt α- and γ-turn conformations are demonstrated by X-ray diffraction, and NMR and FT-IR absorption spectroscopies. Assembled by an Ugi multiple component reaction strategy, Nα-formyl-adamantyl tripeptide iso-propyl and tert-butyl amides are respectively found to adopt an isolated α-turn and an incipient γ-helix conformation by X-ray diffraction crystallography. The shortest example of a single α-turn with ideal geometry is observed in the crystalline state. In solution both peptides predominantly assume γ-helical structures.

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Citations

Dec 18, 2019·Organic & Biomolecular Chemistry·Sergio Di SilvioGennaro Pescitelli
Mar 27, 2021·Journal of Chemical Information and Modeling·Francisco Adasme-CarreñoJoel Ireta

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Methods Mentioned

BETA
X-ray
NMR
dissection

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