Isolated airway exposure to toluene diisocyanate results in skin sensitization

Toxicology Letters
K EbinoM H Karol

Abstract

Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pigs although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to initiate the dermal sensitization. This study sought to determine if exclusive airway exposure to TDI could result in skin sensitivity. A group of guinea pigs was administered 50 microl of 0.6% TDI intratracheally (it.), another group received intranasal (in.) application of 0.6, 1.2, or 1.8% TDI. Eighty percent (4/5) of the it.-dosed animals, and 92% (11/12) of in.-dosed animals exhibited skin sensitivity. None of 14 control animals gave a positive reaction to patch challenge with TDI. These findings indicate that exclusive exposure of the airways to TDI can result in skin sensitivity and suggest that such events may be possible in TDI workers and should be considered in all workers exposed via the airways to chemical sensitizers.

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Citations

May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Qing Liu, Adam V Wisnewski
Jul 1, 2002·Environmental Toxicology and Pharmacology·Anneke H van HouwelingenFrans P Nijkamp
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Carrie A RedlichTerry Gordon
Nov 28, 2012·International Journal of Occupational Medicine and Environmental Health·Dominika Świerczyńska-MachuraCezary Pałczyński
Oct 26, 2005·Archives of Environmental Health·Martin L Pall, Julius H Anderson
Jan 21, 2012·Neurology Research International·Johnathan E LawrenceRobert J Winn
Jul 25, 2015·Regulatory Toxicology and Pharmacology : RTP·Mario ArnoneRemco Visser
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
Mar 17, 2004·Current Opinion in Allergy and Clinical Immunology·Victor J JohnsonMichael I Luster
Sep 1, 2004·Current Protocols in Toxicology·Jean F Regal
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
May 14, 2020·Allergy, Asthma & Immunology Research·Hung Chang TsuiJeroen A J Vanoirbeek

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