PMID: 9530950Apr 8, 1998Paper

Isolated ataxia as an idiosyncratic side-effect under gabapentin

Seizure : the Journal of the British Epilepsy Association
B J SteinhoffC Kurth

Abstract

Gabapentin has been accepted worldwide as a novel antiepileptic drug with a favourable tolerability profile. However, movement disorders have been reported previously as rare side-effects in individual patients. We report on two patients who developed isolated severe ataxia under low-dose gabapentin which resolved abruptly after discontinuation of the drug. This side-effect probably resembled a rare idiosyncratic adverse reaction. We propose the gabapentin-specific neuronal binding site which has a high density in the cerebellum as a possible mechanism of action and suggest that the initiation of gabapentin requires caution if pre-existing cerebellar function impairment is evident.

References

Dec 1, 1993·Drugs·R KälviäinenP J Riekkinen
May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C Short, L Cooke
Oct 1, 1996·Epilepsia·A L ReevesL E Krahn

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Citations

Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·GianPietro SechiGiulio Rosati
Nov 14, 2014·CNS Drugs·J van GaalenB P C van de Warrenburg
May 20, 2015·Expert Opinion on Drug Safety·Dénes ZádoriLászló Vécsei
May 26, 2015·European Journal of Pharmacology·Yang Sook GilHee Jung Baik
Jan 13, 2005·The Annals of Pharmacotherapy·Miguel A Pina, Pedro J Modrego

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