Isolated Distal Deep Vein Thrombosis: Perspectives from the GARFIELD-VTE Registry

Thrombosis and Haemostasis
Sebastian M SchellongAjay K Kakkar

Abstract

Isolated distal deep vein thrombosis (IDDVT) represents up to half of all lower limb DVT. This study investigated treatment patterns and outcomes in 2,145 patients with IDDVT in comparison with those with proximal DVT (PDVT; n = 3,846) and pulmonary embolism (PE; n = 4,097) enrolled in the GARFIELD-VTE registry. IDDVT patients were more likely to have recently undergone surgery (14.6%) or experienced leg trauma (13.2%) than PDVT patients (11.0 and 8.7%, respectively) and PE patients (12.7 and 4.5%, respectively). Compared with IDDVT, patients with PDVT or PE were more likely to have active cancer (7.2% vs. 9.9% and 10.3%). However, influence of provoking factors on risk of recurrence in IDDVT remains controversial. Nearly all patients (IDDVT, PDVT, and PE) were given anticoagulant therapy. In IDDVT, PDVT, and PE groups the proportion of patients receiving anticoagulant therapy was 61.4, 73.9, and 81.1% at 6 months and 45.8, 54.7, and 61.9% at 12 months. Over 12 months, the incidence of all-cause mortality, cancer, and recurrence was significantly lower in IDDVT patients than PDVT patients (hazard ratio [HR], 0.61 [95% confidence interval [CI], 0.48-0.77]; sub-HR [sHR], 0.60 [95% CI, 0.39-0.93]; and sHR, 0.76 [95% CI, 0.60-0.97]...Continue Reading

Citations

May 5, 2020·VASA. Zeitschrift für Gefässkrankheiten·Giovanna ElmiLeonardo Aluigi
Jan 7, 2020·European Heart Journal·Christian HeissVictor Aboyans
Nov 4, 2020·JAMA : the Journal of the American Medical Association·Romain ChopardGregory Piazza
Nov 29, 2020·Journal of Thrombosis and Thrombolysis·Jean-Philippe GalanaudUNKNOWN RIETE Investigators
Nov 21, 2020·International Angiology : a Journal of the International Union of Angiology·Giovanna ElmiPier L Antignani
Mar 24, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Tao QiuXiaoming Zhang
Nov 30, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Gualtiero PalaretiVictor Barinov

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