Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates

Journal of Pediatric Hematology/oncology
Deepak LouisAmita Trehan

Abstract

Rh isoimmunization manifesting as isolated early onset neonatal anemia has not been reported. We describe the presentation of 3 infants who manifested with isolated early severe anemia. All the infants presented early (3 to 7 d of age) with severe pallor. None had clinically significant jaundice. Evidence for hemolysis was present in all and their direct antiglobulin test was positive. To reduce the hemolysis, immunoglobulin was administered after which their hemoglobin improved. This report highlights the possibility of early onset anemia without significant jaundice as the sole manifestation of Rh isoimmunization and the possible beneficial role of immunoglobulin in them.

References

Feb 1, 1986·Pediatric Clinics of North America·J A Stockman
Mar 20, 1998·The New England Journal of Medicine·J I VaughanI A Roberts
Jun 24, 1999·Journal of Perinatal Medicine·S al-Alaiyan, A al Omran
Dec 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·R Gottstein, R W I Cooke
Dec 2, 2009·Pediatrics·Josep Figueras-AloyXavier Carbonell-Estrany

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Citations

Jun 6, 2012·BMJ Case Reports·Juliana RodaDolores Faria Pereira
Oct 11, 2016·British Journal of Hospital Medicine·Gabriela FillonSiba Prosad Paul

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