Isolated extradural Rosai-Dorfman disease of the thoracic spine: a rare cause of spinal cord compression: case report

Neurosurgery
Ahmed H Abou-ZeidKanna K Gnanalingham

Abstract

Rosai-Dorfman disease is a rare benign histiocytic disease of unknown origin that arises predominantly in lymph nodes with generalized fever and malaise but can affect a variety of organs. We describe a case of isolated Rosai-Dorfman disease causing thoracic cord compression. A 24-year-old man presented with progressive spastic paraparesis. A magnetic resonance scan revealed an anteriorly placed extradural lesion of the T4-T7 thoracic spine causing cord compression. He was systemically well with no other disease. The patient made a complete recovery after a limited T4-T7 laminectomy and biopsy of the lesion. Repeat magnetic resonance scan at 6 months revealed a further posteriorly placed lesion at the T8/9 level. More extensive posterior surgery was carried out with subtotal resection of the lesion with pedicle screw fixation. Histologically, all specimens revealed fibrous connective tissue infiltrated by histiocytic cells with CD68 and S100 positivity, confirming a diagnosis of Rosai-Dorfman disease. This is a rare case of isolated Rosai-Dorfman disease causing thoracic cord compression. It should be considered among the differential diagnoses of extradural cord compression. Radiological features and treatment options are disc...Continue Reading

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Citations

Feb 7, 2016·The Spine Journal : Official Journal of the North American Spine Society·Guilherme Lucas de Oliveira LimaNilson Pinheiro Junior
Feb 11, 2016·Surgical Neurology International·Jesús Rocha-MagueyDaniel Montante-Montes de Oca
Nov 16, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sara SciaccaRohit Shetty
Oct 28, 2014·Korean Journal of Spine·Do Young KimKeung Nyun Kim
Feb 9, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Haocheng XuJianyuan Jiang
Sep 4, 2020·Journal of Clinical Orthopaedics and Trauma·Prasad PatgaonkarVivek Patel
Sep 17, 2019·World Neurosurgery·Cheng-Kai Lin, Yu-Duan Tsai

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