Isolated focal dystonia phenotypes are associated with distinct patterns of altered microstructure

NeuroImage. Clinical
Brian D BermanLidia M Nagae

Abstract

Isolated adult-onset focal dystonia is considered a network disorder with disturbances to the motor basal ganglia and cerebellar circuits playing a pathophysiological role, but why specific body regions become affected remains unknown. We aimed to use diffusion tensor imaging to determine if the two most common phenotypes of focal dystonia are associated with distinguishing microstructural changes affecting the motor network. Fifteen blepharospasm patients, 20 cervical dystonia patients, and 30 age- and sex-matched healthy controls were recruited. Maps of fractional anisotropy and mean diffusivity were analyzed using a voxel-based approach and an automated region-of-interest technique to evaluate deep gray matter nuclei. Correlations between diffusion measures and dystonia severity were tested, and post hoc discriminant analyses were conducted. Voxel-based analyses revealed significantly reduced fractional anisotropy in the right cerebellum and increased mean diffusivity in the left caudate of cervical dystonia patients compared to controls, as well as lower fractional anisotropy in the right cerebellum in cervical dystonia patients relative to blepharospasm patients. In addition to reduced fractional anisotropy in the bilatera...Continue Reading

Citations

Sep 12, 2019·Frontiers in Neurology·René-Maxime GracienSimon Baudrexel
Feb 26, 2020·The Cerebellum·Alexey SedovAasef G Shaikh
Oct 18, 2020·Brain Sciences·Thorsten HerrMartin Kronenbuerger
Dec 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Liang FengLingjing Jin
Apr 6, 2021·Movement Disorders Clinical Practice·Nicoletta ManzoLorenzo Rocchi
Jun 30, 2021·Journal of Neural Transmission·Julie GamainMartin Kronenbuerger
Jul 29, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yaomin GuoGang Liu
Sep 1, 2021·Experimental Neurology·Maggie FaganH A Jinnah
May 30, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Rachel E SondergaardDavide Martino

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Methods Mentioned

BETA
imaging technique

Software Mentioned

invwarp
applywarp
SAS
3dClustSim
SPM8
fslstats
FLIRT
DTIfit
FMIRB
AFNI

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