Abstract
To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepatic peliosis, and hepatocellular plate atrophy (HPA). We identified 88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had higher proportion of portal hypertension (53%), ascites (58%), and median AST (113 U/L) and ALT (90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases. Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolat...Continue Reading
References
Jul 17, 1998·British Journal of Cancer·P D PeppercornR K Gupta
Aug 26, 1998·The American Journal of Pathology·P SchirmacherS Rose-John
Oct 2, 1998·The EMBO Journal·D MaioneG Ciliberto
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
Jul 24, 2004·Archives of Pathology & Laboratory Medicine·Sanjay KakarLawrence J Burgart
Sep 14, 2004·Gut·D SaadounD Valla
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrien CroqueloisMarkus H Heim
May 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Timothy M PawlikMichael A Choti
Aug 29, 2007·Clinics in Liver Disease·Basuki K Gunawan, Neil Kaplowitz
Dec 28, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N N MehtaD F Mirza
Feb 15, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S KandutschT Gruenberger
Apr 8, 2011·World Journal of Gastroenterology : WJG·Marek HartlebPiotr Milkiewicz
Dec 28, 2011·Journal of Hepatology·Julie AgostiniPierre Laurent-Puig
Jan 17, 2012·Gastroenterology·Michael T DillDavid Semela
Apr 5, 2013·World Journal of Gastrointestinal Surgery·Qi-Ying LuLin Shen
Feb 17, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiara MarzanoDominique-Charles Valla
Dec 18, 2015·World Journal of Gastroenterology : WJG·Daniele CrocettiGian Luca Grazi