Abstract
Clinical relevance of left ventricular (LV) diastolic dysfunction in the absence of congestive heart failure (CHF) and LV systolic dysfunction is not fully established. Asymptomatic outpatients, sedentary, with cardiovascular risk factors but no history of cardiovascular events, underwent echocardiographic evaluation of LV structure and function by standard Doppler, color M-mode, and Doppler tissue methods, and exercise testing with simultaneous noninvasive assessment of LV stroke index and cardiac index. LV ejection fraction less than 50% and significant valvular disease or stress test suggestive of coronary disease were additional exclusion criteria. In 70 patients selected (40 +/- 10 years old, 63% men, 34% hypertensive, 34% diabetic, 4% diabetic and hypertensive, 11% with LV hypertrophy), LV diastolic dysfunction was detected in 26%, which was associated with hypertension, higher LV mass index, lower systolic function, lower peak exercise heart rate, and chronotropic reserve (all P < .05), and with lower peak exercise stroke index and cardiac index (both covariates adjusted P < .05), but not with lower peak exercise metabolic equivalents (P > .5). Abnormal LV relaxation was independently correlated with lower peak exercise ...Continue Reading
References
Dec 1, 1978·Circulation·D J SahnA Weyman
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jan 1, 1974·Medical & Biological Engineering·L E BakerT D Pate
Jan 1, 1983·Medicine and Science in Sports and Exercise·R D FairshterA F Wilson
Mar 15, 1995·Journal of the American College of Cardiology·G ShimizuK Kawamura
Apr 15, 1996·Circulation·M S LauerD Levy
Dec 15, 1996·Circulation·P M OkinP Kligfield
May 1, 1997·Journal of the American College of Cardiology·E C JonesM J Roman
Jun 17, 1999·Archives of Internal Medicine·W B KannelD Levy
Jul 27, 1999·Journal of Hypertension·G de SimoneM J Roman
Sep 25, 1999·The American Journal of Cardiology·C BriguoriM Chiariello
Aug 25, 2000·European Journal of Applied Physiology·A CharlouxJ Lonsdorfer
Oct 12, 2000·Circulation·S R OmmenA J Tajik
Nov 14, 2000·The American Journal of Cardiology·R B DevereuxB V Howard
Jan 4, 2001·Circulation·V PalmieriR B Devereux
Jan 12, 2001·Journal of the American College of Cardiology·H TanakaD R Seals
May 30, 2001·The American Journal of Cardiology·J N BellaB V Howard
Sep 22, 2001·Hypertension·J N BellaUNKNOWN Hypertension Genetic Epidemiology Network Study Group
May 9, 2002·Circulation·Jonathan N BellaRichard B Devereux
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Dalane W KitzmanKathryn P Stewart
Nov 16, 2002·Journal of Applied Physiology·Linda R PetersonAli A Ehsani
Mar 14, 2003·The American Journal of Cardiology·Carlos Rivas-GotzSherif F Nagueh
Feb 18, 2004·Circulation·Stanislaw J Skaluba, Sheldon E Litwin
Feb 26, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Samer J KhouriThomas E Walsh
Feb 1, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Vittorio PalmieriAldo Celentano
Aug 5, 2005·Journal of Human Hypertension·V PalmieriA Celentano
Citations
Nov 12, 2010·European Journal of Applied Physiology·Chantal A VellaRaul Y Zubia
Oct 11, 2011·Acta Physiologica·C A VellaJ Bader
Oct 17, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mathieu GaydaAnil Nigam
Jul 24, 2014·Journal of the Neurological Sciences·Yohei TateishiIzumi Nagata
Nov 13, 2007·Diabetes Research and Clinical Practice·Vittorio PalmieriAldo Celentano
Jul 3, 2007·International Journal of Cardiology·Kian-Keong PohMalissa J Wood
Mar 10, 2010·European Journal of Heart Failure·Cesare RussoMarco R Di Tullio
Dec 18, 2007·The American Journal of Cardiology·Ibrahim AlmuntaserJohn Feely
Nov 5, 2008·Journal of Atherosclerosis and Thrombosis·Kosuke SakaneKazuhide Yamamoto
Dec 10, 2009·Hypertension·Vittorio PalmieriJonathan N Bella
Jul 15, 2015·Archivos de cardiología de México·Jorge Lara VargasLeopoldo Bueno Ayala
Jun 13, 2019·European Journal of Applied Physiology·Filippo VaccariStefano Lazzer
Nov 2, 2018·Clinical and Experimental Hypertension : CHE·Małgorzata KurpaskaAdam Stańczyk
Dec 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Małgorzata KurpaskaKatarzyna Piotrowicz
Jun 20, 2020·PloS One·Fang LiuYulong Wang