Isolated left ventricular diastolic dysfunction: implications for exercise left ventricular performance in patients without congestive heart failure

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Vittorio PalmieriAldo Celentano

Abstract

Clinical relevance of left ventricular (LV) diastolic dysfunction in the absence of congestive heart failure (CHF) and LV systolic dysfunction is not fully established. Asymptomatic outpatients, sedentary, with cardiovascular risk factors but no history of cardiovascular events, underwent echocardiographic evaluation of LV structure and function by standard Doppler, color M-mode, and Doppler tissue methods, and exercise testing with simultaneous noninvasive assessment of LV stroke index and cardiac index. LV ejection fraction less than 50% and significant valvular disease or stress test suggestive of coronary disease were additional exclusion criteria. In 70 patients selected (40 +/- 10 years old, 63% men, 34% hypertensive, 34% diabetic, 4% diabetic and hypertensive, 11% with LV hypertrophy), LV diastolic dysfunction was detected in 26%, which was associated with hypertension, higher LV mass index, lower systolic function, lower peak exercise heart rate, and chronotropic reserve (all P < .05), and with lower peak exercise stroke index and cardiac index (both covariates adjusted P < .05), but not with lower peak exercise metabolic equivalents (P > .5). Abnormal LV relaxation was independently correlated with lower peak exercise ...Continue Reading

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Feb 1, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Vittorio PalmieriAldo Celentano

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Citations

Nov 12, 2010·European Journal of Applied Physiology·Chantal A VellaRaul Y Zubia
Oct 17, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mathieu GaydaAnil Nigam
Jul 24, 2014·Journal of the Neurological Sciences·Yohei TateishiIzumi Nagata
Jul 3, 2007·International Journal of Cardiology·Kian-Keong PohMalissa J Wood
Dec 18, 2007·The American Journal of Cardiology·Ibrahim AlmuntaserJohn Feely
Nov 5, 2008·Journal of Atherosclerosis and Thrombosis·Kosuke SakaneKazuhide Yamamoto
Jul 15, 2015·Archivos de cardiología de México·Jorge Lara VargasLeopoldo Bueno Ayala
Jun 13, 2019·European Journal of Applied Physiology·Filippo VaccariStefano Lazzer
Nov 2, 2018·Clinical and Experimental Hypertension : CHE·Małgorzata KurpaskaAdam Stańczyk
Dec 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Małgorzata KurpaskaKatarzyna Piotrowicz

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