PMID: 9548607Apr 21, 1998Paper

Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion

Seminars in Surgical Oncology
J F ThompsonC R Harman

Abstract

Isolated limb perfusion (ILP) with cytotoxic agents is an effective but complex procedure. Isolated limb infusion (ILI) has been developed as a simpler alternative. Catheters are inserted percutaneously into the axial artery and vein of the affected limb and a pneumatic tourniquet is inflated proximally. Cytotoxic agents are then infused through the arterial catheter and circulated with a syringe for 15 to 20 minutes. Progressive hypoxia occurs, but normothermia is maintained. To date, 175 ILIs have been performed: 164 for melanoma and 11 for other tumours. Results obtained are similar to those obtained by conventional ILP. Morbidity is low and treatment of frail and elderly patients who would not tolerate ILP is possible. An elective double ILI protocol can be used to obtain the additional benefits of fractionated chemotherapy. The possibility of increasing ILI response rates by using other drugs and drug combinations and by multiple fractionated dosing is being investigated.

References

Feb 1, 1978·The Australian and New Zealand Journal of Surgery·B R Love
Feb 1, 1979·The Journal of Surgical Research·C P KarakousisE D Holyoke
Feb 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D W SiemannA Beikirch
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·D J ChaplinP L Olive
Aug 1, 1988·British Journal of Cancer·I J StratfordN Timpson
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·J WieberdinkG A Olthuis
Mar 1, 1982·Cancer·C P KarakousisJ H Ewing
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B B KroonJ A van Dongen
Mar 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S A van de MerweJ van der Zee
Oct 1, 1996·The British Journal of Surgery·B C VrouenraetsB B Kroon
Aug 1, 1997·Archives of Surgery·J F ThompsonP C Kam

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Citations

Aug 3, 2013·Current Oncology Reports·Malcolm Hart Squires, Keith A Delman
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A TestoriA M M Eggermont
Apr 9, 2009·Annals of Surgical Oncology·Hidde M KroonJohn F Thompson
Oct 16, 2009·Annals of Surgical Oncology·Andrew P BarbourB Mark Smithers
Apr 25, 2012·Annals of Surgical Oncology·Anna M HuismansJohn F Thompson
Dec 5, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Nasreen A VohraJonathan S Zager
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·John F Thompson, Peter C A Kam
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G M BeasleyD S Tyler
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mecker G MöllerJonathan S Zager
Jan 19, 2010·Expert Opinion on Drug Metabolism & Toxicology·Alfredo A Santillan, Jonathan S Zager
Jul 8, 2010·Expert Opinion on Drug Metabolism & Toxicology·Peter C A Kam, John F Thompson
Dec 17, 2009·Expert Opinion on Pharmacotherapy·James PadsisDouglas Tyler
Dec 17, 2009·Expert Opinion on Pharmacotherapy·Jonathan S Zager, Keith A Delman
Mar 1, 2012·Surgical Oncology Clinics of North America·Jeremiah L Deneve, Jonathan S Zager
May 10, 2011·Current Problems in Surgery·Amira SankiJohn F Thompson
Oct 16, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S R GrobmyerS N Hochwald
Oct 26, 2007·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Z Al-HilliA D K Hill
Feb 3, 2009·The Surgical Clinics of North America·Katharine YaoDavid J Winchester
Aug 30, 2008·Surgical Oncology Clinics of North America·James H Muchmore, Harold J Wanebo
Aug 30, 2008·Surgical Oncology Clinics of North America·Peter C A Kam, John F Thompson
Jun 15, 2007·Seminars in Oncology·Dan G BlazerMichael S Sabel
Nov 22, 2005·The Veterinary Clinics of North America. Equine Practice·Alison J Morton
Apr 15, 2009·Journal of Surgical Oncology·Hidde M Kroon, John F Thompson
Jan 24, 2014·Journal of Surgical Oncology·Claire F Temple-OberleJ Gregory McKinnon
Dec 10, 2013·Journal of Surgical Oncology·Jonathan SteinmanMary S Brady
Jan 1, 2014·Journal of Surgical Oncology·Hidde M KroonJohn F Thompson
Sep 25, 2012·ANZ Journal of Surgery·João Pedreira Duprat NetoJosé H Fregnani
Nov 18, 2004·American Journal of Surgery·Tomio UenoDouglas S Tyler
Nov 4, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J J BonenkampP C A Kam

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