Isolated limb perfusion for melanoma

Surgical Oncology Clinics of North America
B B KroonO E Nieweg

Abstract

Isolated limb perfusion with high-dose chemotherapy is an accepted treatment modality to achieve locoregional control in advanced melanoma of the extremities. The drug of choice is melphalan. Tumor necrosis factor-alpha is frequently added to melphalan in bulky disease, and this combination may be an option for repeat perfusion for recurrent melanoma after a first perfusion. Results of perfusions performed with tissue temperatures between 37 degrees C and 38 degrees C seem to be equivalent to those of the perfusions performed under mild hyperthermic conditions. Perfusion cannot be recommended as an adjunct to wide local excision in patients who have primary melanoma. Adjuvant perfusion in repeatedly recurrent limb melanoma, however, may be of value because it lengthens the limb recurrence-free interval and decreases the number of lesions per recurrence significantly. Regional toxicity of perfusion should be mild when risk factors are taken into account.

References

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M KlaaseH R Franklin
May 1, 1994·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J M KlaaseJ van der Zee
Mar 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·S A van de MerweJ van der Zee
Jan 1, 1996·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·B C VrouenraetsJ A van Dongen
Dec 11, 1997·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L J StrobbeB B Kroon
Mar 13, 2002·Annals of Surgical Oncology·Per LindnérJohn F Thompson
Aug 18, 2004·Annals of Surgical Oncology·Eva M NoordaBin B R Kroon
Nov 17, 2004·Archives of Surgery·Eva M NoordaBin B R Kroon
Aug 16, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D J GrünhagenA M M Eggermont
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy R CornettUNKNOWN American College of Surgeons Oncology Group Trial Z0020
May 30, 2008·Annals of Surgical Oncology·Hidde M KroonJohn F Thompson

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Citations

Jul 16, 2013·Current Problems in Surgery·Erik M Dunki-JacobsKelly M McMasters
Nov 17, 2009·Clinics in Plastic Surgery·Christopher J Hussussian
Sep 29, 2009·The Surgical Clinics of North America·Gorav Ailawadi, Richard K Zacour
Oct 16, 2009·Annals of Surgical Oncology·Andrew P BarbourB Mark Smithers
Jan 4, 2020·Environmental Monitoring and Assessment·Mohsen JalaliFaranak Ranjbar
Dec 17, 2009·Expert Opinion on Pharmacotherapy·James PadsisDouglas Tyler

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