PMID: 9429225Jan 16, 1998Paper

Isolated limb perfusion with fotemustine after chemosensitization with dacarbazine in melanoma

Melanoma Research
L PontesM C Azevedo

Abstract

Isolated limb perfusion (ILP) has been reported as the most effective treatment for localized recurrent melanoma of the limbs. In terms of local and regional control with melphalan, complete remission is achieved in about 40% of patients, with frequent toxicity causing significant short-term disability in many and long-term incapacity in a few. Since 1989, several studies have reported success using a combination of fotemustine and dacarbazine (DTIC) in the systemic treatment of disseminated melanoma and brain metastasis. In May 1995, we began a pilot study with systemic DTIC 400 mg/m2 given intravenously about 4 h before ILP using fotemustine in an intra-arterial bolus of 100-150 mg/m2 as the perfusion agent. By July 1996, 10 patients had been included in the study. The results were evaluated in terms of the response rate (five complete responses and one partial response in the six patients who could be evaluated), local toxicity (nine patients with level I and one with level II, measured on the Wieberdink scale) and systemic toxicity (nine patients with level 0 and one with level 1, measured on the World Health Organization scale). Treatment was effective, with a similar response rate to that obtained with melphalan but with ...Continue Reading

Citations

Aug 10, 2002·Seminars in Oncology·Carlo Riccardo RossiMario Lise
Nov 15, 2011·Expert Opinion on Pharmacotherapy·Gaëlle Quéreux, Brigitte Dréno
May 10, 2011·Current Problems in Surgery·Amira SankiJohn F Thompson
Nov 4, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J J BonenkampP C A Kam

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