PMID: 12788409Jun 6, 2003Paper

Isolated limb perfusion with melphalan in the treatment of malignant melanoma of the extremities: a systematic review of randomised controlled trials

The Lancet Oncology
Marko B Lens, Martin Dawes

Abstract

Isolated limb perfusion is a surgical procedure for delivering a high dose of chemotherapeutic or immunochemotherapeutic agent to a localised area, thus avoiding the severity of side-effects caused by systemic administration. This technique is generally used for treatment of patients with tumours of the limbs and extremities. We have done a systematic review of randomised controlled trials assessing the effectiveness of this treatment in patients with melanoma of the extremities. Four trials of 1038 patients met our inclusion criteria and were analysed. Although our analysis confirmed the reported increase in survival in two of the trials, neither had sufficient power to detect significant benefit for perfusion. Results from the trials showed that prophylactic perfusion has an equivocal effect on survival in patients with limb melanoma. Therefore, current evidence suggests that prophylactic isolated limb perfusion cannot be recommended as a routine adjunct to standard surgery in patients with high-risk primary limb melanoma, but only as a treatment for local disease control if other forms of locoregional therapy are not available.

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Citations

Oct 27, 2015·Journal of Neurosurgery. Spine·Athos PatsalidesYves Pierre Gobin
Jan 29, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A BhanguA Desai
Nov 18, 2015·Annals of Surgical Oncology·Adam K BrysPaul J Mosca
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Jan 1, 2013·Healthcare·Eshini PereraRodney Sinclair
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Mar 13, 2015·Cancer Research·Aleksandra M Dudek-PerićPatrizia Agostinis
Mar 13, 2021·Surgical Oncology Clinics of North America·Jennifer H AldrinkMary Austin
May 31, 2020·Cancer Treatment Reviews·Tara D BaetzTeresa M Petrella

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