Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience

Annals of Surgery
A M EggermontF J Lejeune

Abstract

The objective of the study was to achieve limb salvage in patients with locally advanced soft tissue sarcomas that can only be treated by amputation or functionally mutilating surgery by performing an isolated limb perfusion (ILP) with tumor necrosis factor (TNF) + melphalan (M) as induction biochemotherapy to obtain local control and make limb-sparing surgery possible. To increase the number of limb-sparing resections in the treatment of locally advanced extremity soft tissue sarcoma, preoperative radiation therapy or chemotherapy or a combination of the two often are applied. The ILP with cytostatic agents alone is another option but rarely is used because of rather poor results. The efficacy of the application of TNF in ILP markedly has changed this situation. In 8 cancer centers, 186 patients were treated over a period of almost 4.5 years. There were 107 (57%) primary and 79 (43%) recurrent sarcomas, mostly high grade (110 grade III; 51 grade II; and 25 very large, recurrent, or multiple grade I sarcomas). The composition of this series of patients is unusual: 42 patients (23%) had multifocal primary or multiple recurrent tumors; median tumor size was very large (16 cm); 25 patients (13%) had known systemic metastases at th...Continue Reading

References

May 1, 1977·Annals of Surgery·E T KrementzI Hutton
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Dec 11, 1975·American Journal of Surgery·J S StehlinR F Anderson
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J GaynorM F Brennan
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D LienardF J Lejeune
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·M H ShiuM F Brennan
Aug 1, 1988·The Journal of Experimental Medicine·P NawrothD Stern
Aug 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FeinbergJ U Gutterman
Jul 1, 1986·Cancer·D A PotterS A Rosenberg
Apr 1, 1986·International Journal of Radiation Oncology, Biology, Physics·H D Suit, J E Tepper
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·M TrojaniC Lagarde
Oct 1, 1982·European Journal of Cancer & Clinical Oncology·J WieberdinkG A Olthuis
Jul 1, 1995·The Journal of Pathology·N RenardD J Ruiter
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A K ThomD L Fraker
Jun 1, 1994·The Annals of Thoracic Surgery·H W PogrebniakH I Pass
Jan 1, 1994·CA: a Cancer Journal for Clinicians·C C BoringS Montgomery
Aug 1, 1993·The British Journal of Surgery·S HillJ M Thomas
Sep 1, 1993·The British Journal of Surgery·J M KlaaseH R Franklin
Apr 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E R ManusamaA M Eggermont
Jan 1, 1996·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·P T NooijenD J Ruiter
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M EggermontF J Lejeune

❮ Previous
Next ❯

Citations

Apr 21, 1998·Seminars in Surgical Oncology·B C VrouenraetsB B Kroon
Jul 14, 1999·Seminars in Surgical Oncology·K K Hunt, B W Feig
Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·R LucasL Fransen
Sep 28, 2005·Cancer Immunology, Immunotherapy : CII·Koji Tamada, Lieping Chen
Nov 6, 2009·International Journal of Colorectal Disease·Thilo SchäferWerner Lindemann
Dec 21, 2000·Current Oncology Reports·B W Feig
Aug 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ángel Montero LuisJosé Antonio López Martín
Dec 4, 2012·Indian Journal of Surgical Oncology·Samit PurohitK Govindbabu
Jun 8, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Angelo CortiVanesa Gregorc
Jun 14, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M G A van IjkenA M M Eggermont
Jun 3, 2000·The Surgical Clinics of North America·J P Greelish, J S Friedberg
Aug 10, 2000·Current Surgery·R B Redd, F L Greene
Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P H NijhuisH J Hoekstra
Oct 31, 1998·Current Opinion in Immunology·F J LejeuneD Liénard
May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S TomekM Krainer
Jun 6, 2003·The Lancet Oncology·René VethTheo Wobbes
Jul 10, 2003·The Lancet Oncology·Alexander M M EggermontTimo L M ten Hagen
Oct 24, 2003·Breast Cancer Research and Treatment·Christoph C ZielinskiChristoph Wiltschke
Feb 8, 2006·Nature Clinical Practice. Oncology·Dirk J GrünhagenAlexander M M Eggermont
Jun 4, 2008·Sarcoma·R J OlsenS H Hinrichs
Nov 4, 2004·Journal of the National Cancer Institute·Flavia BrunsteinTimo L M ten Hagen
Nov 11, 2003·Journal of Pediatric Hematology/oncology·Peter Hohenberger, Per Ulf Tunn
May 15, 2002·The Cancer Journal·Nancy M Carroll, H Richard Alexander
Jul 31, 2009·Journal of Biomechanical Engineering·Raghav GoelJohn C Bischof
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven K LibuttiLawrence Tamarkin

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