PMID: 6968620Oct 15, 1980Paper

Isolated marrow lymphoma: an entity of possible T-cell derivation

Cancer
J C BartonR T Parmley

Abstract

Seven adults had a distinct clinicopathologic type of lymphoproliferative disorder of the bone marrow. All patients presented with weakness and pancytopenia; no evidence of gross extramedullary involvement was found. In 5 cases severe and prolonged bone marrow hypoplasia was associated with combination chemotherapy; 1 patient died of infection during initial therapy. In 6 of the 7 cases, clinical improvement occurred following therapy. As a terminal event, 2 patients developed a leukemic phase. Tumor cell from 4 patients were studied immunologically, and in 2 patients surface marker characteristics suggestive of T-cell tumor origin were found. In 2 cases, ultrastructural studies of lymphoid cells were compatible with a T-cell neoplasm. The above data suggest that these cases represent a distinct type of chemotherapy-sensitive lymphoma in which conservative initial treatment may induce a response without prolonged bone marrow hypoplasia.

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Citations

Sep 1, 1992·Hematological Oncology·K F WongC H Chan
Sep 3, 2011·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Yuki KagoyaKazuhito Hatanaka
Mar 1, 1984·Journal of Clinical Pathology·R BartlG Hoffmann-Fezer
Oct 18, 2011·Internal Medicine·Tohru TakahashiMasayuki Tsujisaki
Jan 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E KohanD A Terreros
Jan 1, 1994·Mayo Clinic Proceedings·M Ponzoni, C Y Li
Oct 1, 1986·Pathology·A ManoharanW R Pitney

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