Isolated metastasis to the gallbladder from hepatocellular carcinoma

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Masahiro MurakamiHiroaki Nagano

Abstract

Metastasis to gallbladder (GB) from hepatocellular carcinoma (HCC) is rare, and it is difficult to determine indications for surgery. We report eight cases of synchronous isolated GB metastasis, and analyze their features retrospectively. Among 439 HCC patients who underwent hepatectomy from 1998 to 2008 at our institution, 393 (89.5%) underwent concurrent cholecystectomy. Among them, eight (1.8%) had GB metastasis without other distant metastases. None of these cases showed evidence of direct invasion. All cases had advanced portal vein thrombus (PVTT) and their main tumor located near the GB bed. Five cases had apparent tumor mass in the GB wall, and the other three cases had only tumor thrombus in the GB veins. Six cases were treated postoperatively with local infusion therapy with interferon, and three of them showed long-term survival. Our eight cases of GB metastasis from HCC were closely related to PVTT. Surgical resection and multimodal treatment would be necessary for long-term survival in cases with isolated GB metastasis.

References

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Citations

Dec 30, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sofía de la SernaJuan-Carlos García-Valdecasas
Jun 30, 2012·International Journal of Surgery Case Reports·Masaki WakasugiToshirou Nishida
Jun 18, 2021·Surgical Case Reports·Takaaki HanazawaTsuyoshi Sano
Jul 15, 2021·Insights Into Imaging·Giulio CoccoCosima Schiavone

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