Isolated midbrain ischemic infarct in association with hyperlipoproteinemia (a): a report of 2 adolescent patients

Journal of Pediatric Hematology/oncology
Srivandana AkshintalaYaser Diab

Abstract

Arterial ischemic strokes (AIS) localized solely to the midbrain are extremely uncommon in the pediatric population. Elevated lipoprotein (a), which promotes atherosclerosis and a prothrombotic state, has been associated with increased risk of AIS in children and adults. Here we describe a 17-year-old boy and a 15-year-old girl who presented with internuclear ophthalmoplegia secondary to an isolated midbrain AIS. Evaluation for risk factors for AIS in these otherwise healthy adolescents identified hyperlipoproteinemia (a) in combination with other potential prothrombotic conditions suggesting that hypercoagulable states such as hyperlipoproteinemia (a) may have contributed to development of small-vessel arteriopathy and localized AIS.

References

Jun 19, 2004·Pediatric Hematology and Oncology·Emel CangözNejat Akar
Jul 26, 2005·Thrombosis Research·Chris Barnes, Gabrielle Deveber
Aug 26, 2006·Stroke; a Journal of Cerebral Circulation·Tetsuya OhiraAaron R Folsom
Jul 23, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Dec 22, 2009·The Journal of Pediatrics·Timothy J BernardNeil A Goldenberg
Mar 10, 2011·Nature Reviews. Neurology·Lori C Jordan, Argye E Hillis
Dec 23, 2011·European Neurology·Katsuhiko OgawaSatoshi Kamei
Mar 2, 2012·Frontiers of Neurology and Neuroscience·Jorge Moncayo

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