PMID: 2497642May 1, 1989Paper

Isolated presence of antibody to hepatitis B core antigen in dialysis patients: occurrence of subclinical hepatitis?

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
K N LaiH J Lin

Abstract

Hepatitis B core antibody (anti-HBc) has recently been recognized as a paradoxical (surrogate) marker for non-A, non-B hepatitis agents in donated blood. We studied prospectively the hepatitis B virus antigen and antibody status and liver functions in 63 uremic patients admitted consecutively to our dialysis program. Nineteen percent of uremic patients, negative for hepatitis B surface antigen (HBsAg), hepatitis B virus surface antibody (anti-HBs), hepatitis B virus DNA, and antibody to delta agents, had anti-HBc in their sera at the time of admission to maintenance dialysis. This prevalence was significantly higher than that of the medical personnel working in the dialysis unit (P = 0.043) and healthy controls (P = 0.027). The prevalence of persistent presence of isolated anti-HBc increased to 31% in these uremic patients on long-term maintenance dialysis. Four patients had developed anti-HBc alone during their course of maintenance dialysis, and the appearance of anti-HBc was preceded by blood transfusion within 4 to 8 weeks. Transient or recurrent hepatic dysfunction occurred in three of these four patients. Patients with isolated anti-HBc were characterized by a higher incidence of repeated liver dysfunction (P less than 0....Continue Reading

References

Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
Oct 1, 1976·Transplantation·G Opelz, P I Terasaki
Feb 25, 1974·JAMA : the Journal of the American Medical Association·W SzmunessG Vyas

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Citations

Aug 1, 1990·Kidney International·L J JeffersR Duncan
Aug 13, 2011·Kidney & Blood Pressure Research·Alicja E GrzegorzewskaPaweł P Jagodziński
Sep 30, 2005·Hemodialysis International·Sydney Tang, Kar Neng Lai
Mar 1, 1992·Journal of Gastroenterology and Hepatology·G C ChanE K Yeoh

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