PMID: 6537692Nov 1, 1984Paper

Isolated production of aldosterone by a malignant adrenal carcinoma

The Yale Journal of Biology and Medicine
D S LevineB H Forman

Abstract

A 45-year-old female developed hypertension and hypokalemia. Elevated plasma aldosterone and suppressed plasma renin levels were measured with no evidence for glucocorticoid or androgen abnormalities. A left adrenal tumor was removed that showed histologic criteria for malignancy. It is commonly taught that malignant adrenal tumors are recognized by their multiple hormone production. However, isolated aldosterone production by a carcinoma can occur and requires close follow-up observation and therapy for this highly malignant tumor.

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