Isolated prostate cancer soft tissue recurrence 10 years after radical prostatectomy

BMJ Case Reports
Munad KhanJoseph Ischia

Abstract

In advanced disease, prostate cancer is well known to invade locally as well as metastasise to distant locations. Metastases occur commonly in lymph nodes and bone but have also been known to involve certain visceral organs, particularly the lungs. Involvement of soft tissue by metastases is far less common, particularly in the context of cancer recurrence. We present the case of a male aged 68 years who presented with a rising prostate-specific antigen (PSA) 10 years after radical prostatectomy (RP). The PSA increased despite salvage radiotherapy and was ultimately found to be caused by a PSA secreting prostate cancer soft tissue mass in the suprapubic region. Surgical resection of the mass caused a sharp decline in the PSA to negligible levels. This case highlights the need for ongoing surveillance post-RP and the potential for prostate cancer recurrence in the soft tissue that is refractory to routine salvage radiotherapy.

References

Jul 1, 1992·European Journal of Pediatrics·L Schweigerer, T Fotsis
Oct 1, 1993·The Journal of Urology·V S KassabianP T Scardino
Aug 1, 1997·Diseases of the Colon and Rectum·R A AllardyceP F Bagshaw
Nov 20, 1998·Surgical Endoscopy·L N TsengH J Bonjer
Feb 14, 2006·Nature Clinical Practice. Urology·John F Ward, Judd W Moul
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Bruce J TrockPatrick C Walsh
Jan 4, 2012·Histopathology·Peter A Humphrey
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger

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