Isolated relapse of acute lymphoblastic leukemia in the breast of a young female

Pediatric Hematology and Oncology
K TodoS Todo

Abstract

A 20-year-old female developed a relapse of B-precursor acute lymphoblastic leukemia (ALL) as a mass in her left breast after 6 years of maintained continuous complete remission. No leukemic lesions were identified in other sites such as the bone marrow or cerebrospinal fluid. The relapsed leukemic cells in the breast revealed the same immunophenotypes (CD10(+), CD19(+), CD20(+), HLA-DR(+), CD34(+)) as those of the onset ALL cells in the bone marrow. A literature survey found 10 other cases of ALL relapse in the breast without bone marrow involvement, mostly consisting of adolescent girls. Including the present report, a total of 11 cases were analyzed; the onset ages of ALL were a median of 16.5 (range 5-50) years old and the ages of relapse in the breast a median of 20 (range 12-51) years old. Data suggest that, although rare, the breast could become one of the extramedullary relapse sites of ALL developed in adolescent girls.

References

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Citations

Jan 31, 2012·American Journal of Hematology·Isabel Cunningham
Nov 1, 2013·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Suk Jung Kim
Jan 27, 2016·Journal of Adolescent and Young Adult Oncology·Amy B HoughtelinEmmanuel Katsanis
Jan 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Anna LuzurierPascal Merlet
Apr 13, 2012·Acta Radiologica·Alexey SurovJasmin Abbas

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